The root cause of acute myocardial infarction (AMI) was postulated way back in in 1912 by James Herrick who proposed it to be thrombotic occlusion of the coronary artery [1,2]. This hypothesis prioritized thrombolytic agents into the line of treatment which could remove thrombotic occlusion, restore blood supply to myocardium and prevent or limit the extent of myocardial damage. Hume et al in 1...

The effects of beta-adrenergic blockade on cardiac transcapillary exchange were examined at rest and during sympathetic stimulation. Multiple indicator dilution experiments were carried out in closed-chest anesthetized dogs at rest and during carotid occlusion, either under basal conditions or after beta-adrenergic blockade with alprenolol. beta-Adrenergic blockade at rest had no effect on coro...

The resistance to coronary blood flow in various parts of the myocardium was studied with the tracer microspheres technique before and immediately after an acute coronary occlusion and several weeks after a more slowly occurring coronary occlusion by Ameroid constrictor. All experiments were carried out in the isolated, metabolically supported, empty, beating dog heart at maximal coronary vasod...

The differential diagnosis for ST-segment elevation myocardial infarction in young patients without traditional risk factors for coronary artery disease often includes coronary artery vasospasm, dissection, and pericarditis. However, in the setting of focal, sustained arterial closure, one must again revisit a platelet-mediated mechanism. We report a case of platelet-mediated occlusion due to e...

In the setting of acute myocardial infarction, pharmacologic intervention resulting in afterload changes are common but the effect of these changes on regional left ventricular function, and specifically the functional border zone, has not been fully investigated. Accordingly, we studied the effects of afterload manipulation on circumferential flow-function relationships and the functional bord...

BACKGROUND Despite numerous reports that one or more episodes of brief coronary artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct size produced by a subsequent prolonged ischemia, we recently demonstrated that preconditioning does not attenuate contractile dysfunction in the peri-infarct tissue. However, the specific effects of preconditioning on myocardi...

MALLIANI, ALBERTO, PETER J. SCHWARTZ, and ALBERTO ZANCHETTI. A sympathetic rejex elicited by experimental coronary occlusion. Am. J. Physiol. 217(3): 703-709. 1969.-The effects of transient coronary occlusion on a sympathetic outflow presumably directed to the heart have been studied on cats. Single preganglionic fibers and a few multifiber strands have been isolated from the left third thoraci...

Specific rabbit anti-cardiolipin (anti-CL) antibodies were used to investigate the hypothesis that cardiolipin, associated with mitochondrial membrane proteins, binds Cl and facilitates activation of the complement cascade following reperfusion of ischemic myocardium. By immunoelectron microscopy, anti-CL localized to subsarcolemmal mitochondria, emerging through breaks in membranes of damaged ...

We evaluated the effect of altered loading conditions on left ventricular (LV) diastolic pressurevolume relations during acute coronary artery occlusion that was produced by inflation of an intracoronary balloon. Open-chest anesthetized dogs (n=18) were instrumented so that LV pressure (micromanometer) and LV volume (conductance) could be measured without disturbing the pericardium. The effects...