PURPOSE To explore the potential effect of ageing on the corneal curvature and corrected visual acuity in patients with long-term keratoconus because of the paucity of these patients older than 50 years. METHODS Records of keratoconic patients, who had initially presented to a specialized contact lens clinic and followed for more than 20 years after disease onset, were reviewed. Collected inf...

PURPOSE Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant (ACV(R)) HSV-1 and clinical consequences thereof in patients with recurrent HSV-1 keratitis (rHK). METHODS F...

The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value. Clinically, the corneal dystrophies can be divided into three groups based on the sole or predominant anatomical location of the abnormalities. Some affec...

The purpose of this study was to evaluate the effects of different time combinations of dexamethasoneand acetylcysteine on experimentally induced corneal ulcers in dogs. Experimental corneal wounds werecreated surgically to the anterior one third of the cornea in the center of all eyes of 15 mixed breed dogs. The eyes were divided into five groups according to planned post-operative medications...

purpose: congenital corneal leukoma is rare with an incidence of 6/100000 and is one of the most important causes of amblyopia. here we report an unusual case of bilateral congenital elevated corneal leukoma. methods: we encountered a 13-day-old full term male newborn. ocular examination of both eyes revealed central elevated corneal leukomas with a narrow normal lucid interval to limbus. corne...

Purpose: To correlate corneal endothelium cell density with dry eye disease compared to an age-matched control group. Materials and Methods: In this cross-sectional study, a total of 150 eyes of 75 female students aged 19-25 years who did not have any history of eye injuries or eye disease affecting the corneal endothelium cell density, were recruited from KSU Female Campus. They were divided i...

Report keratoconus in two patients with a long history of wrestling without any risk factor for corneal ectasia and reviewing the possible pathogenesis. To confirm suspicion of keratoconus, corneal topography was performed using scanning slit topography system and Orbscan. In two wrestlers with the complaint of visual loss in their eyes and IOP raising, corneal topography was performed and de...

PURPOSE In scanning laser polarimetry with variable corneal compensation (SLP-VCC), the macula is used as an intraocular polarimeter to calculate and neutralize corneal birefringence based on an intact Henle's layer. The purpose of this investigation was to validate this strategy in eyes with macular structural disease. METHODS A nerve fiber analyzer was modified to enable the measurement of ...

Twitching motility is a form of surface-associated bacterial movement mediated by type IV pili of Pseudomonas aeruginosa. Others have shown that pilT and pilU mutants, which are piliated but defective in twitching motility, display reduced cytotoxic capacity towards epithelial cells in vitro. Although these mutants efficiently infected lungs in vivo, they were defective in dissemination to the ...

We investigated whether IL-10 produced endogenously would influence the development of HSV-1-induced acute corneal disease. Murine corneal epithelial cells and fibroblasts cultured in vitro expressed IL-10 mRNA and protein constitutively and also IL-10 receptors. Inclusion of IL-10 neutralizing antibody in the culture medium significantly (p<0.05) enhanced TNF-alpha-induced IL-6 and MIP-2 produ...