PURPOSE No theory or method currently exists to preoperatively predict the optimal position of an intracorneal implant for the treatment of keratoconus, or a surgical system or technique to adjust and optimize the position of the implant after its implantation. A surgical technique for adjusting the position of the implant inside the cornea is presented, and by adjusting the position of the imp...

In the cornea, the precise organisation of fibrillar collagen and associated proteoglycans comprising the stromal extracellular matrix plays a major role in governing tissue form and function. Recently, abnormal collagen alignment was noted in the misshapen corneas of mature chickens affected by the retinopathy, globe enlarged (rge) mutation. Here we further characterize corneal ultrastructural...

PURPOSE To determine whether in vivo confocal microscopy (IVCM) of the cornea can be used for the label-free detection and monitoring of lymph vessels in live corneas. METHODS Parallel corneal hemangiogenesis and lymphangiogenesis was induced by the placement of a single suture in one cornea of male Wistar rats. Fourteen days after suture placement and under general anesthesia, laser-scanning...

PURPOSE To examine the effects of transcorneal freezing using a new cryoprobe designed for corneal endothelial surgery. METHODS A freezing console employing nitrous oxide as a cryogen was used to cool a series of different cryoprobe tip designs made of silver for high thermal conductivity. In vitro studies were conducted on 426 porcine corneas, followed by preliminary in vivo investigations o...

PURPOSE To investigate normal anterior segment parameters and analyze the possible influencing factors using a dual Scheimpflug system. SETTING Department of Ophthalmology, Affiliated Sixth People's Hospital Shanghai Jiao Tong University, Shanghai, China. DESIGN A prospective observational case series. METHODS A total of 153 normal subjects (153 eyes) were studied. The anterior segment pa...

Purpose To map the corneal epithelium using a map measuring 9 mm in diameter and view the effects of age, sex, and axial length. Additionally, we wanted to demonstrate the reproducibility of this technique. Methods We calculated the epithelial thickness in 220 individuals using an SD-OCT machine with the newly released commercially available algorithm. We included normal eyes with refractive ...

We report here the ultrastructural organization of collagen fibrils (CF) and proteoglycans (PGs) of the corneal stroma of both the stingray and the shark. Three corneas from three stingrays and three corneas from three sharks were processed for electron microscopy. Tissues were embedded in TAAB 031 resin. The corneal stroma of both the stingray and shark consisted of parallel running lamellae o...

BACKGROUND To investigate the association between pretreatment corneal parameters and orthokeratology lens decentration. METHODS This retrospective study included a total of 108 eyes in 60 myopia patients, who were divided into a lens-decentration and a control group. Various pretreatment corneal parameters were analyzed by receiver operating characteristic curves (ROC curves), including corn...

PURPOSE This study investigated short-term corneal changes induced by reverse-geometry lenses worn for orthokeratology. METHODS Nine young adult subjects wore reverse-geometry rigid gas-permeable lenses (BE; UltraVision Contact Lenses, Brisbane, Australia) in one eye only for 10, 30, and 60 min in the open eye and 8 h in the closed eye. The fellow eye acted as a non-lens-wearing control. Corn...

BACKGROUND/AIMS Current contact lenses (CLs) when worn on an extended wear basis cause corneal epithelial alterations. The aim of this study was to evaluate changes in corneal epithelial cell morphology and physiology following short term (3 months) wear of highly oxygen permeable CLs and to compare this with disposable CLs. METHODS Subjects were wearers of highly oxygen permeable CLs (n=11, ...