PURPOSE To investigate the clinical features of Korean patients with congenital aniridia. METHODS This retrospective study focused on 60 eyes from 31 patients who were diagnosed with congenital aniridia at Kangnam St. Mary's Hospital from 1996 to 2007. Patient age, gender, visual acuity (VA), family history, and previous ocular history were recorded. The presence of keratopathy, glaucoma, cat...

BACKGROUND To compare the clinical efficacy of lidocaine 2% with tetracaine 0.5% for cataract surgery. METHODS In a randomized, multi-surgeon, controlled clinical trial,122 consecutive cataract cases eligible for topical anesthesia, were randomly assigned to receive lidocaine 2% gel (1 ml) or tetracaine solution 0.5% (TetraVisc, 0.5 ml) before clear corneal phacoemulsification. Main outcome m...

Since alkaline substances can rapidly penetrate into the cornea and subsequently damage limbal stem cells, another source of stem cells may be necessary to reconstruct the ocular surface. Omentum has some such characteristics like ability to regenerate tissue as well as anti-inflammatory capacity. Presence of adult stem cells and pluripotent embryonic cell markers make it suitable in wound heal...

The retrospective study was conducted to determine the indications and outomes of penetrating keratoplasty(PKP) in a tertiary care setting in Pakistan. All eyes that had undergone PKP between January 2005 and December 2014 at the Aga Khan University Hospital, Karachi, were included.Data were collected on the indications of PKP, graft survival (graft clarity at final follow-up), andbest correcte...

Invasion of the corneal stroma by neutrophils and eosinophils and subsequent degranulation disrupts corneal clarity and can result in permanent loss of vision. In the current study, we used a model of helminth-induced inflammation to demonstrate a novel role for Ab in mediating recruitment of these inflammatory cells to the central cornea. C57BL/6 and B cell-deficient (microMT) mice were immuni...

AIM To study corneal stromal changes and the presence of myofibroblasts after transplantation of ex vivo expanded limbal epithelium. METHODS A state of limbal deficiency was induced in 16 rabbits. After transplantation with autologous ex vivo expanded limbal epithelium on amniotic membrane (AM), their clinical outcomes were classified as success, partial success or failure according to surfac...

DURING the early stage of our experiments on the use of low temperature for cataract extraction (Krwawicz, 1961, 1963), we had several opportunities of observing the effects of accidentally touching the cornea with the cryoextractor refrigerated to about -79°C. This accident proved to be quite harmless in all cases as no lasting effect on the clarity of the cornea could be seen after the tissue...

Aim: A cohort study to evaluate the factors that contribute to opacification of a corneal graft following Penetrating Keratoplasty. Material and Methods: This cohort study consisted of 40 patients (40 eyes), of opacified graft after penetrating keratoplasty. Thirty patients were studied retrospective for 5 years and 10 patients prospectively for 2 years. The various clinical parameters in all t...

To evaluate the use of photorefractive keratectomy (PRK) with mitomycin C (MMC) application as a therapeutic and refractive solution for low to moderate myopic patients with granular corneal dystrophy (GCD) type 1, to study the postoperative complications and the recurrence rate, and to answer this question: Can excimer laser ablation obviate the need for keratoplasty in those patients?. Prospe...