PURPOSE To describe the distribution and determinants of intraocular pressure (IOP) and indices of corneal biomechanics in an adult British population. METHODS Goldmann-equivalent IOP (IOPg), corneal mechanical characteristics (corneal hysteresis, CH; corneal resistance factor, CRF), and IOP adjusted for corneal factors (IOPcc) were measured. Ocular biometric characteristics were also measure...

PURPOSE To investigate possible corneal biomechanical changes in patients with diabetes mellitus and understand the influence of such changes on intraocular pressure measurements. METHODS The study group was composed of 120 eyes from 61 healthy control subjects and 81 eyes from 43 diabetic subjects. IOP was measured first with an ocular response analyzer (ORA) and subsequently with a Goldmann...

PURPOSE To investigate the biomechanics of the anterior human corneal stroma using atomic force microscopy (AFM). METHODS AFM measurements were performed in liquid on the anterior stroma of human corneas, after gently removing the epithelium, using an atomic force microscope in the force spectroscopy mode. Rectangular silicon cantilevers with tip radius of 10 nm and spring elastic constants o...

Glaucoma is one of the most dreadful ocular conditions that affects millions of people worldwide and is one of the major causes of irreversible blindness. Although glaucoma is a complex and poorly understood disorder, the primary goal of therapy is lowering Intraocular Pressure (IOP), which is not only one of the most significant risk factors in development of the disease, but also the only mod...

We read with great interest the article by Kanellopoulos and Asimellis1 and the subsequent correspondence with Reinstein et al.2 with the debate regarding the law that drives epithelial remodeling and the healing process. Kanellopoulos and Asimellis explained their findings of epithelial thickening after myopic LASIK with their hypothesis that epithelial behavior is related to the biomechanics ...

Purpose. To evaluate the difference in biomechanical properties between contact lens induced corneal warpage and normal and keratoconic eyes. Method. Prospective observational case control study, where 94 eyes of 47 warpage suspicious and 46 eyes of 23 keratoconic patients were included. Warpage suspected cases were followed until a definite diagnosis was made (warpage, normal, or keratoconus)....