INTRODUCTION New (188)Re and (99m)Tc peptide conjugates with substance- P (SP) were prepared and biologically evaluated. The radiopharmaceuticals have been labelled with the [M≡N](2+) (M=(99m)Tc, (188)Re) core using a combination of π-donor tridentate and π-acceptor monodentate ancillary ligands. METHODS The new radiopharmaceuticals have been prepared through a two-step reaction by simultaneo...

The limitations on the sensitivity for detecting small changes in MRI, CT, and ultrasound pulse-echo images are used to estimate the practical requirements for molecular imaging and targeted contrast enhancement for these modalities. These types of imaging are highly unlikely to approach the sensitivity for detecting molecular processes of radionuclear methods, and the prospects for achieving s...

This paper presents a systematic analysis of the inherent uncertainty in internal dose calculations for radiopharmaceuticals. A generic equation for internal dose is presented, and the uncertainty in each of the individual terms is analyzed, with the relative uncertainty of all terms compared. The combined uncertainties in most radiopharmaceutical dose estimates will be typically at least a fac...

Radiation dose measurements of radiopharmaceuticals and calibrators at different voltages fluctuations were evaluated. Low high doses technetium, iodine fluorine pharmaceuticals measured in voltages. The results showed that only low could make small insignificant differences.

The field of nuclear imaging and therapy is rapidly progressing with the development targeted radiopharmaceuticals that show rapid targeting clearance minimal background. Unfortunately, they are often reabsorbed in kidneys, leading to possible nephrotoxicity, limiting therapeutic dose, and/or reducing quality. blocking endocytic receptors has been extensively used as a strategy reduce kidney ra...