significant advances have been made in diagnosis and therapy of demyelinating disorders of the central nervous system. the most common entities of this disorders in adults – multiple sclerosis and neuromyelitis optica were initially thought to be different phenotypes of more or less the same disease. during the last ten years, this view was subsequently changed and the term neuromyelitis optica...

dementia is defined as significant acquired cognitive impairment in one or more cognitive domains that represents a significant decline from previous baseline and interferes with independence in daily activities. autoimmune dementia is a term that has been used to describe a steroid-responsive autoimmune disorder characterized by a rapidly progressive dementia with a fluctuating course. even co...

The long-term effects of impairment have a negative impact on the quality life stroke patients in terms not using affected limb even after some recovery (i.e., learned non-use). Immersive virtual reality (IVR) has been introduced as new approach for treatment rehabilitation. We propose an IVR-based therapeutic to incorporate positive reinforcement components motor coordination opposed constrain...

Previous studies on fine and gross motor skills of children with childhood apraxia speech (CAS) have reported inconclusive results. In this study, we investigate the abilities CAS by focusing three distinct factors: control during movement, skills/handwriting, general coordination. Participants included 25 20 age-matched typically developing (TD) between ages 5 7 years. Motor were evaluated usi...

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that leads to progressive disability in young adults. A variety of neurological deficits such as motor weakness, spasticity, and ataxia may lead to significant walking gait impairment. The degree of this impairment is associated with severe dysfunction of various neurological systems such as alterations in muscle pow...

The worldwide mental health burden associated to COVID-19. psychological symptoms COVID-19 can originate from three different sources: lockdowns, pandemic life and virus infection (both post condition). Within the it be found: anxiety, depression, post-traumatic stress, fatigue cognitive impairment (i.e., ’brain fog’, slowness, deficits in attention, executive functioning, working memory, learn...

A double blind study was performed to evaluate the ability of trained police officers to detect drug impairments and to identify the type of drug responsible for the impairment, on the basis of observed symptoms and psychophysical measurements of performance alone. The officers were not allowed to interview the subjects, and their conclusions were based solely on observable signs and symptoms o...

Gabapentin decreases the level of glutamate and elevates that of alpha-amino-butyric acid in the central nervous system. Gabapentin was shown to have antinociceptive effects in several facilitated pain models. Intrathecal gabapentin was also known to be effective in reducing mechanical allodynia in animals with neuropathic pain. In this study, we investigated to see whether intrathecal gabapent...

Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sensory integration, motor coordination, and motor sequencing. The vulnerability ...

Within the domain-general theory of language impairment, this study examined body posture and hand movement imitation in children with specific language impairment (SLI) and in their age-matched peers. Participants included 40 children with SLI (5 years 3 months to 6 years 10 months of age) and 40 children with typical language development (5 years 3 months to 6 years 7 months of age). Five tes...