BACKGROUND Due to time-dependent confounding by blood pressure and differential loss to follow-up, it is difficult to estimate the effectiveness of aggressive versus conventional antihypertensive combination therapies in non-randomized comparisons. METHODS We utilized data from 22,576 hypertensive coronary artery disease patients, prospectively enrolled in the INternational VErapamil-Trandola...

Uptoone-thi rd of all nursing home residents, primarily patients with dementia, receive antipsychotic medications for the treatment of symptoms of psychosis, agitation, and aggression (1). In patients with dementia, the presence of psychosis or agitation predisposes to worse long-term outcomes, including a higher rate of institutionalization and death (2). Antipsychotic medications that are use...

ulcerative colitis is a mucosal-inflammatory disease that usually involves the rectum and extends proximally to involve all or part of the colon. medications for treatment include anti-inflammatory agents such as 5-asa compounds, systemic and topical corticosteroids and immunomodulators. a 33 year-old female and 52 year-old male both diagnosed with severe active ulcerative colitis who were resi...

purpose: to compare the short and long-term efficacy and complications of releasable suture vs conventional interrupted suture for scleral flap in trabeculectomy. methods: in a prospective randomized clinical trial, 42 eyes of 42 consecutive patients requiring trabeculectomy for uncontrolled primary glaucoma underwent conventional trabeculectomy (group a) and trabeculectomy with releasable sutu...

In schizophrenia patients, both an older age and earlier age at onset of the disease are related to worse cognitive functioning. As patients with later schizophrenia onset are also older, analysing the two effects separately can be misleading, as they can either be spurious or cancel one another out. The purpose of the present study was to elucidate the effects of age and onset-age on cognition...

BACKGROUND Antipsychotic monotherapy or polypharmacy (concurrent use of two or more antipsychotics) are used for treating patients with psychiatric disorders (PDs). Usually, antipsychotic monotherapy has a lower cost than polypharmacy. This study aimed to predict the cost of antipsychotic medications (AM) of psychiatric patients in Iran. MATERIALS AND METHODS For this purpose, 790 patients wi...

BACKGROUND Conventional antipsychotics augmented with benzodiazepines have been the standard acute treatment for psychiatric emergencies for more than 50 years. The inability of patients to give informed consent limits randomised, controlled studies. This observational study on immediate therapy for aggression and impulse control in acutely agitated patients (IMPULSE) evaluated the short-term e...

Despite widespread agreement that nursing homes' use of antipsychotic medications for residents without specific psychiatric diagnoses is a marker of poor quality of care, prevalence remains high. Additionally, variation suggests continued opportunity to improve care even in countries, like the United States, that have long-standing policies designed to decrease antipsychotic medication use. In...