نتایج جستجو برای: controlled drug release
تعداد نتایج: 1116695 فیلتر نتایج به سال:
Background and purpose: Pharmaceutical aspects of mucoadhesion have been the subject of great interest during recent years because it provides the possibility of avoiding either destruction by gastrointestinal contents or hepatic first-pass inactivation of drug. In this study, polysaccharide mucilage derived from the seeds of Plantago major L. (Plantaginaceae family) was investigated for use in...
Mesoporous silica nanoparticles with unique structure (SBA-15) were synthesized and modified by [3-(2-Aminoethylamino) propyl] trimethoxysilane (AEAPTMS). The synthesized nanoparticles were characterized by TGA, N2 adsorption, SEM, FTIR, CHN elemental analysis. The total weight loss for the modified SBA-15 is 15.2% and thermal analysis reveal...
Drug release kinetics plays an important role in determining the mechanism of drug release, which in turn helps in formulating controlled/sustained release formulations.In our study, different concentrations of green tea polyphenols (GTP) were encapsulated into casein nanoparticles which showed a maximum encapsulation efficiency (76.9%) at a GTP concentration of 5 mg/mL. The casein nanopa...
Drug release kinetics plays an important role in determining the mechanism of drug release, which in turn helps in formulating controlled/sustained release formulations.In our study, different concentrations of green tea polyphenols (GTP) were encapsulated into casein nanoparticles which showed a maximum encapsulation efficiency (76.9%) at a GTP concentration of 5 mg/mL. The casein nanopa...
the aim of this study is to prepare novel sorbitol based extended release tablets by melt dispersion method using carbamazepine as a model drug. carbamazepine was melted along with sugar alcohol to get melt dispersion granules (mgds) and was characterized by differential scanning calorimetry (dsc), powder x-ray diffractometry (xrd) and solubility study. the physical and chemical parameters of m...
Background and Purpose: Oral administrations have been used for many years as a main method comparing to other methods. Sustained release techniques have been a great interest recently. Matrix polymers are one of the ways used to prepare a sustained-release drug and are most widely used to prepare the controlled-release drugs. Cellulose derivatives are the most common ones. Solubilities of so...
Background and purpose: The potential of liquisolid systems for increasing drug dissolution has been proved in many researches. Recent studies have shown that liquisolid technique is a new and promising method for controlling the dissolution rate of drugs. Based on thermal treating effect on polymer structure, in this study the effects of thermal treating on theophylline release from liquisolid...
Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...
this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...
mesoporous silica nanoparticles with unique structure (sba-15) were synthesized and modified by [3-(2-aminoethylamino) propyl] trimethoxysilane (aeaptms). the synthesized nanoparticles were characterized by tga, n2 adsorption, sem, ftir, chn elemental analysis. the total weight loss for the modified sba-15 is 15.2% and thermal analysis revealed that 1.5 mmol aeaptms/1g sba-15 had been grafted...
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