Objectives To assess the efficacy of a new investigative treatment a non-inferiority study is undertaken when it is no longer ethical to have a placebo control. Instead an active controlled trial is undertaken. The objective is thus to show that the new treatment is no worse than the active control. In analysing a non-inferiority trial, the following ABC needs to be considered [1]: 1. The Assay...

introduction: the purpose of this article was to evaluate the quality of sample size calculation reports in published clinical trials in journal of endodontics and international endodontic journal in years 2000-1 and 2009-10. materials and methods: articles fulfilling the inclusion criteria were collected. the criteria were: publication year, research design, types of control group, reporting s...

background: infantile colic, cry-fuss and sleep problems are transient in the initial months of life, but they contribute to maternal depression, parenting stress and family mental health problems. in this randomized clinical trial, we aimed to explore the efficacy of massage therapy compared to rocking in reducing infantile colic symptoms including duration and number of cries, sleep duration ...

background: degenerative joint disease (djd) is the most common joint disease in human beings. previous studies have explained that glucosamine is preferred as placebo and in efficacy compared with nsaid’s in treatment of patients’ knee osteoarthritis. alendronate was used to treat osteoporotic patients and its efficacy was established. objectives: the aim of this study was to compare the effic...

attention-deficit/hyperactivity disorder is one of the most common mental disorders in childhood, and it continues to adulthood without proper treatment. stimulants have been used in the treatment of attention-deficit/hyperactivity disorder (adhd) for many years, and the efficacy of methylphenidate in the treatment of adults with adhd has been proven to be acceptable according to meta-analysis ...

background to evaluate the effectiveness of acupuncture and compare it with fluoxetine in treatment of fibromyalgia syndrome (fms). methods we conducted a prospective, randomized clinical trial. fifteen patients were treated with acupuncture and compared with a control group (n=15) of patients who received fluoxetine. visual analogue scale, fibromyalgia impact questionnaire (fiq) and determined...