Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we bri...

Skin ageing is a complex process that is determined by both intrinsic and extrinsic factors, which leads to a progressive loss of structure and function. There is extensive evidence indicating that oxidative stress induced by reactive oxygen species plays an important role in the process of human skin ageing. Mitochondria are the major source of cellular oxidative stress and are widely implicat...

The ageing of asphalt mixes, together with their exposure to low temperatures, causes a progressive increase of cracking. In this paper, the effect of ageing and temperature on the fatigue of asphalt concretes made with two types of binders, conventional (50/70) and polymer modified bitumen (PMB), is studied. For this purpose, specimens previously subjected to an accelerated laboratory ageing p...

The factors necessary to obtain an optimal heat treatment that influence the hardness and resistivity of Al-6Si-0.5Mg casting alloys with Cu or/and Ni additions were investigated. The alloys were homogenised (24hr at 500C), solutionized (2hr at 540C) and artificially ageing at various times and temperatures. The alloys were aged isochronally for 60 minutes at temperatures up to 400C and isother...

This paper examines the contributions that generativity in older age maymake to the concept of successful ageing. To this end, two perspectives on successful ageing are described: successful ageing as a set of clinical criteria, and successful ageing as the application of adaptive processes aimed at achieving efficient functioning. After showing the limitations of the first perspective, particu...

Studies in invertebrate model organisms have led to a wealth of knowledge concerning the ageing process. But which of these discoveries will apply to ageing in humans? Recently, an assessment of the degree of conservation of ageing pathways between two of the leading invertebrate model organisms, Saccharomyces cerevisiae and Caenorhabditis elegans, was completed. The results (i) quantitatively ...

abstract statement of problem: mechanical strength and durability of dental composites are the main topics studied in this field of science today. this study examined fumed silica-based composite as a strong and durable restorative material through flexural and cycling test methods.     objectives: the purpose of this study was to evaluate the effect of silanization, ageing, cycling and hybridi...

reduced-activation ferritic/martensitic steels have been developed by replacing molybdenum by tungsten and niobium by tantalum in commercial elevated-temperature cr–mo steels to reduce half-life of radioactive isotopes. the objective of this study was to investigate tensile properties of a reduced-activation ferritic/martensitic steel (9cr-2wvta) in normalized-tempered (nt) and quenched-tempere...

Increased life expectancy has led to policy interest in adding quality to years of life and in related concepts such as attitudes to ageing. Improving attitudes to ageing is regarded as one means of improving the participation and contribution of older people within society. In considering agerelated attitudes in the dynamic nature of social identity, age is not just one social category that ma...

BACKGROUND The public health policy agenda oriented towards healthy ageing becomes the highest priority for the European countries. The article discusses the healthy ageing concept and its possible determinants with an aim to identify behavioral patterns related to healthy ageing in selected European countries. METHODS The healthy ageing is assessed based on a composite indicator of self-asse...