the purpose of this investigation was to study the effect of variability of practice and age on retention and transfer of the over-arm throwing accuracy in children. khalajy and shafizadeh’s (1383) test of over-arm throwing accuracy was adjusted and used in this study. 48 right-handed female children (16 children in each age group of 4, 5 and 6 years old) were selected voluntarily. each age gro...

The elemental composition of animals, or their organismal stoichiometry, is thought to constrain their contribution to nutrient recycling, their interactions with other animals, and their demographic rates. Factors that affect organismal stoichiometry are generally poorly understood, but likely reflect elemental investments in morphological features and life history traits, acting in concert wi...

Ferritin is an iron storage protein of wide distribution. The protein, apoferritin, is composed of 24 subunits arranged as a spherical shell with outside diam. 13 nm and inner cavity width -8 nm [I] . Up to 4500 Fe atoms can be stored in this space in the form of a ferric oxhydroxide microcrystalline core. It has been shown that apoferritin catalyses the oxidation of Fe(I1) to Fe(II1) [2-51 and...

Phosphorylation reduces the lifetime and activity of activated G protein-coupled receptors, yet paradoxically shifts the metarhodopsin I-II (MI-MII) equilibrium (K(eq)) of light-activated rhodopsin toward MII, the conformation that activates G protein. In this report, we show that phosphorylation increases the apparent pK for MII formation in proportion to phosphorylation stoichiometry. Decreas...

Qiang Zhu,1,2,* Li Li,3 Artem R. Oganov,1,2,3,4 and Philip B. Allen3 1Department of Geosciences, Stony Brook University, Stony Brook, New York 11794, USA 2Center for Materials by Design, Institute for Advanced Computational Science, Stony Brook University, New York 11794, USA 3Department of Physics and Astronomy, Stony Brook University, Stony Brook, New York 11794, USA 4Department of Problems o...

Chlorophyll (Chl) is widely taken as a proxy for phytoplankton biomass, despite well-known variations in Chl:C:biomass ratios an acclimative response to changing environmental conditions. For the sake of simplicity and computational efficiency, many large scale biogeochemical models ignore this flexibility, compromising their ability capture dynamics. Here we evaluate modelling approaches diffe...

The chimeric anti-CD30 IgG1, cAC10, conjugated to eight equivalents of monomethyl auristatin E (MMAE) was previously shown to have potent antitumor activity against CD30-expressing tumors xenografts in mice. Moreover, the therapeutic index was increased by lowering the stoichiometry from 8 drugs/antibody down to 2 or 4. Limitations of such 'partially-loaded' conjugates are low yield (10-30%) as...

A Competitive spectrophotometric method has been used for the study of complexation between Cu2+, Zn2+ and Cd2+ (M) and 18-crown-6(18C6, B) in methanol using 4-(2-thiazolylazo) resorcinol (TAR, HL) as the colorimetric complexant. Absorption spectra of the species in the M-TAR-18 C6 system at a various concentrations of 18C6 showed no formation of ternary com...

DsbA is the major oxidase responsible for generation of disulfide bonds in proteins of E. coli envelope. In the present work we provided the first detailed characterization of disulfide exchange between DsbA and its natural substrate, HtrA protease. We demonstrated that HtrA oxidation relies on DsbA, both in vivo and in vitro. We followed the disulfide exchange between these proteins spectroflu...