Cognitive processes involve multiple mechanisms that interact in complex and possibly idiosyncratic ways. This complexity likely underlies the general lack of meaningful impact of monopharmacological (or “magic bullet”’) approaches to brain dysfunction, including cognitive decline and dementia. For example, the cholinesterase inhibitors used in the treatment of Alzheimer’s disease (AD) have a n...

BACKGROUND Several studies have shown that a small but significant percentage of cancer patients decline one or more conventional cancer treatments and use complementary and alternative medicine (CAM) instead. OBJECTIVES Here, drawing on the literature and on our own ongoing research, we describe why cancer patients decide to decline conventional cancer treatments, who those patients are, and...

Some countries have introduced mandatory folic acid fortification, whereas others support periconceptional supplementation of women in childbearing age. Several European countries are considering whether to adopt a fortification policy. Projections of the possible beneficial effects of increased folic acid intake assume that the measure will result in a considerable reduction in neural-tube def...

STUDY OBJECTIVES Little is known about long-term effects of pneumonectomy on lung function and exercise tolerance. We evaluated the long-term validity of two formulas frequently used to predict postoperative lung function, as well as trends in postoperative lung function and late postoperative exercise capacity. SETTING Nonuniversity teaching hospital of Eindhoven, the Netherlands. PATIENTS...

Rates of remyelination decline with age and this has been attributed to slower recruitment of oligodendrocyte progenitor cells (OPCs) into areas of demyelination and slower differentiation of OPCs into remyelinating oligodendrocytes. When considering causes for reduced recruitment rates, intrinsic causes (alterations in biological properties of OPCs) need to be separated from extrinsic causes (...

Rather than being an inevitable consequence of age, cognitive decline can occur with marked variation among individuals. In this context, nutrition is one factor that is believed to be influential. When considering the potential role of diet, two factors need to be considered. First, cognitive or brain reserve is said to decrease the incidence of dementia; that is, it has been suggested that th...

Effect of the strengthened western Pacific subtropical high on summer visibility decrease over eastern China since 1973" (2013). [1] Daily visibility (Vis) data from 354 meteorological stations are used to evaluate the seasonal Vis trends over China from 1973 to 2009, which show that Vis decline is most distinct over eastern China in summer, with a trend of À1.4 km per decade or À34% in the 37 ...

BACKGROUND Postoperative delirium is a frequent complication in elderly patients undergoing major abdominal surgery and is associated with a poor outcome. We compared postoperative delirium in elderly patients following laparoscopic gastrectomy (LG) versus open gastrectomy (OG). METHODS In total, 130 patients aged ≥ 65 years with gastric cancer undergoing LG and OG were enrolled prospectively...

The emergence of corona virus (COVID-19) has create a great public concern as the outbreak is still ongoing and government are taking actions such as holiday extension, travel restriction, temporary closure of public work place, borders, schools, quarantine/isolation, social distancing and so on. To mitigate the spread, we proposed and analyzed a stochastic model for the continue spread of coro...