PURPOSE The mechanism of larynx oncogenesis is complex and controlled by various factors, most of them involved in cell proliferation and apoptosis. In this study, we evaluated the levels of two suppressor proteins (pRb and p53) and two oncogenic proteins (c-Myc and Bcl-2), as well as the apoptotic levels and the presence of human papillomavirus (HPV) in both tumor types. EXPERIMENTAL DESIGN ...

Vulvar vestibular papillomatosis is considered an anatomical variant of the vulva. Recognition of this condition enables one to distinguish it from warts and therefore avoid unnecessary therapy. A 29-year-old lady presented to this clinic with a history of 'small growths' in her vulva since two years. Examination identified skin colored translucent papules; some of them appeared digitate and we...

UNLABELLED Evidence of a relation between gastroesophaeal reflux and pediatric respiratory disorders increases every year. Many respiratory symptoms and clinical conditions such as stridor, chronic cough, and recurrent pneumonia and bronchitis appear to be related to gastroesophageal reflux. Some studies have also suggested that gastroesophageal reflux may be associated with recurrent laryngeal...

1. Welch JM, Nayagam M, Parry G, Das R, Campbell M, Whatley J, et al. What is vestibular papillomatosis? A study of its prevalence, aetiology and natural history. Br J Obstet Gynaecol 1993;100:939‐42. 2. Wollina U, Verma S. Vulvar vestibular papillomatosis. Indian J Dermatol Venereol Leprol 2010;76:270‐2. 3. van Beurden M, van der Vange N, de Craen AJ, Tjong‐A‐Hung SP, ten Kate FJ, ter Schegget...

Sir, Stevens-Johnson syndrome (SJS) is a rare and severe mucocutaneous disorder, most frequently caused by systemic drugs, with an incidence of 1–6 cases per million person-years (1). It is characterized clinically by a maculopapular and bullous eruption with epidermal necrosis and detachment, mucosal ulcers and erosions and constitutional signs and symptoms. SJS and toxic epidermal necrolysis ...

Les manifestations neurologiques centrales du syndrome de Gougerot-Sjögren primitif (SGS) sont très polymorphes, parmi lesquelles les pachyméningites représentent l'une des manifestations les plus rares, elles sont exceptionnellement révélatrices. Patient âgé de 40 ans présente depuis 7 ans des céphalées fronto-orbitaires gauches pulsatiles avec sonophotophobie. Depuis un an, les céphalées sont...

Neutrophils generate microbicidal oxidants through activation of a multicomponent enzyme called NADPH oxidase. During activation, the cytosolic NADPH oxidase components (p47, p67, p40, and Rac2) translocate to the membranes, where they associate with flavocytochrome b558, which is composed of gp91/NOX2 and p22, to form the active system. During neutrophil stimulation, p47, p67, p40, and p22 are...

In an electron microscope study on the developmental cycle of the goat pneumonitis strain of Chlamydia psittaci in L cells, it was observed that miniature reticulate bodies, measuring approximately 0.2 mum in diameter and surrounded by double unit membranes, were produced infrequently from normal-sized reticulate bodies through a "budding"-like process. As little as 0.1 mug of penicillin per ml...

A previously healthy patient was seen in the Emergency Department for evaluation of a one-month history of cough and one-day history of hemoptysis. This case report, from a pulmonologist's perspective, includes a comprehensive review of the patient's clinical presentation and outcome, as well as a discussion of recurrent respiratory papillomatosis.