Uveal melanoma cell cycling, quantified by bromodeoxyuridine (BrdUrd)-labeling index and mitotic index, is predictive of tumor-related mortality. Serial sections from 36 formalin-fixed melanoma specimens were labeled with BrdUrd and stained with hematoxylin and eosin. All tumors were assessed for the area of highest cell cycling activity and counts for mitotic figures and BrdUrd labeling were p...

Diets with a high glycemic index and glycemic load have been hypothesized to be implicated in the etiology of colorectal cancer owing to their potential to increase postprandial glucose and insulin levels. Prospective data on glycemic index and glycemic load in relation to colorectal cancer risk are limited and inconsistent. Therefore, the authors prospectively investigated the associations of ...

Measurements and main results: Relative to subjects with a respiratory disturbance index of less than 5.0 events/hour (the reference category), subjects with mild SDB (5.0–14.9 events/hour) and moderate to severe SDB (≥15 events/hour) had adjusted odds ratios of 1.27 (95% confidence interval: 0.98, 1.64) and 1.46 (95% confidence interval: 1.09, 1.97), respectively, for fasting glucose intoleran...

OBJECTIVE To determine the prevalence of overweight and obesity in British young people (4-18 years) in 1997. DESIGN Cross-sectional analysis of the National Diet and Nutrition Survey of young people. SETTING Great Britain. SUBJECTS Nationally representative sample of 1836 young people (age 4-18 years). RESULTS The prevalence of obesity based on body mass index (weight/height(2)) and th...

OBJECTIVE To explore why reports that seem to describe randomised controlled trials are sometimes not indexed ("tagged") with RCT (randomised controlled trial) [pt] (publication type) in Medline. Design Cross sectional study. SETTING The Cochrane Collaboration and US National Library of Medicine worked together to identify and retag records of randomised controlled trials with RCT [pt], 1994 ...

OBJECTIVES To examine the reporting characteristics and methodological details of randomised trials indexed in PubMed in 2000 and 2006 and assess whether the quality of reporting has improved after publication of the Consolidated Standards of Reporting Trials (CONSORT) Statement in 2001. DESIGN Comparison of two cross sectional investigations. Study sample All primary reports of randomised tr...

PURPOSE A number of longitudinal studies have tracked blood pressure over time in children and adults. Although there are a few blood pressure tracking studies for Asian populations, they are all relatively short-term studies with around only 10 years of follow-up. Accordingly, we assessed the stability of blood pressure tracking from childhood to adulthood over a 24-year follow-up period among...

OBJECTIVE This article examined whether occupational factors predicted 4-year change in body mass index (BMI) in a sample of full-time Australian employees. METHODS Data from 1670 full-time Australian employees were collected through the Longitudinal Study of Australian Children. Multinomial logistic regression was used to examine whether several occupational factors at baseline predicted cha...

RATIONALE Critical periods for programming early wheeze risk may include pregnancy and infancy. Effects of timing remain poorly understood. OBJECTIVES Associations among prenatal and postnatal maternal stress and children's wheeze were prospectively examined in 653 families. Effect modification by maternal sensitization was also examined. METHODS Stress was indexed by a maternal negative li...