Iroquois homeobox (Irx) family members, a group of highly conserved homeodomain containing transcription factors, are involved in the patterning and the proper functions of vertebrate organs. They can act as transcriptional activators or repressors in a context-dependent manner. Preliminary data indicated that Irx3 and Irx5 are functionally redundant during cardiac morphogenesis, and they physi...

Morphological findings in sural nerves were related to nerve conduction in 12 patients with diabetic neuropathy, five with mainly sensory involvement, four with severe, symmetrical sensory-motor polyneuropathy, and three with multiple mononeuropathy. All had loss of large and small myelinated and of unmyelinated fibres, even early in the disease; segmental remyelination was the most prominent m...

Due to the quick development of wide bandgap power devices, density converters is expected be much higher. In order increase and efficiency dual-active-bridge (DAB) converter, especially under light load, a quasi-optimal current root-mean-square (rms) control strategy achieve All-zero-voltage switching (ZVS) proposed by taking inductor rms optimization algorithm into account in this article. Fi...

We present an interesting image showing sequential loss of anterograde, and subsequently, retrograde conduction during radiofrequency ablation of an accessory pathway. We discuss the possible mechanisms and prior literature concerning this interesting finding.

OBJECTIVES The goal of this study was to investigate the genotype-to-phenotype relationship between SCN5A gene mutation and progressive cardiac conduction defect in order to gain insights into the pathophysiologic mechanisms of the disease. BACKGROUND Progressive cardiac conduction defect is a frequent disease commonly attributed to degeneration and fibrosis of the His bundle and its branches...

OBJECTIVE To determine functional results after lateral semicircular canal fenestration on congenital conductive hearing loss. STUDY DESIGN Case series with chart review. SETTING Amir-Alam otolaryngology tertiary referral center. SUBJECTS AND METHODS Twenty patients with congenital oval window malformations who were not candidates for ossicular reconstruction underwent lateral semicircula...

Otosclerosis is the most frequent cause of conductive hearing loss in patients with intact tympanic membrane. It can be treated by surgery with various techniques. Because of limited manipulation and comparably similar results, stapedotomy at present is preferred over other surgical techniques by most surgeons. Here we present the operative results of 114 otosclerotic patients who underwent sta...

Synchronous rectifiers are widely used in low voltage and high current DC/DC converters to reduce conduction power loss. For popular and reliable topologies, such as Half-bridge, Push-pull and Phase-shifted Full-bridge, the application of self-driven synchronous rectification has design challenges due to the existence of dead times. Existing solutions are not suitable for wide input voltage ran...