OBJECTIVES The objectives of this study were to evaluate the occurrence and severity of complications after mandibular distraction osteogenesis (DO) with internal devices. STUDY DESIGN The study was a retrospective analysis of 131 patients (mean age: 16.2 years) consecutively treated by mandibular DO from 1998 to 2009. Ninety-two patients had unilateral and 39 had bilateral distraction, yield...

Background: Distraction osteogenesis is a method of producing unlimited quantities living bone directly from special osteotomy (cortico to my). Advances in methods external fixation have made limb lengthening feasible option achieved by distraction osteogenesis. Complex trauma cases such as failure fractures unite after several attempts, significant soft tissue infection, loss ab initio, the pr...

OBJECTIVE Umbilical mesenchymal stem cells (UMSCs) is one of most popular regenerative medical source of bone replacement therapy in both clinical and scientific researches. However, it is still low effective to induce the osteogenesis of hUMSCs. In this study, we aimed to elucidate the roles of DNA methyltransferase 3B (DNMT3B) in the osteogenesis of hUMSCs. MATERIALS AND METHODS Knockdown D...

Osteogenesis imperfecta is a genetic disorder of type I collagen. Although multiple genotypes and phenotypes are associated with osteogenesis imperfecta, approximately 90% of the mutations are in the COL1A1 and COL1A2 genes. Osteogenesis imperfecta is characterized by bone fragility. Patients typically have multiple fractures or limb deformity; however, the spine can also be affected. Spinal ma...

Distraction osteogenesis is a powerful technique for creating new bone during significant lengthening of the mandible without the need for bone grafting and associated donor site morbidity. The majority of clinical applications of mandibular lengthening with distraction osteogenesis techniques reported in the literature are in growing patients.1-8 For the purposes of this article, an adult pati...

137 Children affected with osteogenesis imperfecta (OI) have increased morbidity and mortality and no definite treatment has been found yet. Recurrent fractures and bone deformities are the main complications of this disease. Recent studies have shown the ability of intravenous pamidronate to prevent fractures, when given in a cyclical manner [1]. This treatment is being used currently to preve...

statement of problem: it is not known whether endochondral and intramembranous bones have distinct biological characteristics. octacalcium phosphate (ocp), a hydroxyapatite precursor, has been reported to stimulate bone formation after being implanted in parietal bone defects of rats. purpose: the present study was designed to investigate the response of endochondral and intramembranous bones t...

The benefits of physical loading to skeletal mass are well known. primary cilium has emerged as an important organelle in bone mechanobiology/mechanotransduction, particularly mesenchymal stem/stromal cells, yet the molecular mechanisms mechanotransduction poorly understood. In this study, we demonstrate that Gpr161 is a mechanoresponsive GPCR, localises cilium, and involved fluid shear-induced...

Osteogenesis imperfecta is a disease characterized by increased fragility of the bones which are easily fractured by slight trauma. Patients suffering from this disorder usually have blue sclerae and flaccid ligaments; some of them become deaf later in life. Scattered reports of this disorder date back at least to 1678 (quoted by Seedorff in 1949). Vrolik (1849) described the disease in the new...