To clarify the relationships between islet antibodies (islet cell antibody [ICA], GAD antibody [GADA], and IA-2 antibody [IA-2A]) versus the progression of beta-cell dysfunction, we have followed a group of diabetic patients from their diagnosis at 21-73 years of age. Patients with ICA had high levels of GADA and/or IA-2A at diagnosis and a more severe beta-cell dysfunction 5 years after diagno...

‎In this paper we characterize Bergman spaces with‎ ‎respect to double integral of the functions $|f(z)‎ ‎-f(w)|/|z-w|$,‎ ‎$|f(z)‎ -‎f(w)|/rho(z,w)$ and $|f(z)‎ ‎-f(w)|/beta(z,w)$,‎ ‎where $rho$ and $beta$ are the pseudo-hyperbolic and hyperbolic metrics‎. ‎We prove some necessary and sufficient conditions that implies a function to be...

background: hb a2 is elevated in subjects with beta thalassemia minor but small percent of carriers have normal hb a2 with elevated levels of hbf (2-10%). this type of thalassemia is called delta beta thalassemia, and can be missed in pre-marriage hematologic consults or screening which leads to increased risk of child birth with beta thalassemia major. materials and methods: in this prospectiv...

BACKGROUND Cognitive and physical functions are closely linked in old age, but less is known about this association in midlife. Whether cognitive function predicts physical function and whether physical function predicts cognitive function were assessed in middle-aged men and women. METHODS Data were from Whitehall II, an ongoing large-scale, prospective occupational cohort study of employees...

Baker (2019), Barany and Kaenmaki (2019) independently showed that there exist iterated function systems without exact overlaps are super-exponentially close cylinders at all small levels. We adapt the method of obtain further examples this type. prove for any algebraic number \(\beta\ge 2\) real numbers \(s, t\) such system \(\left \{\frac{x}{\beta}, \frac{x+1}{\beta}, \frac{x+s}{\beta}, \fr...

We examined interactions between base excision repair (BER) DNA intermediates and purified human BER enzymes, DNA polymerase beta (pol beta), apurinic/apyrimidinic endonuclease (APE1) and poly(ADP-ribose) polymerase-1 (PARP-1). Studies under steady-state conditions with purified BER enzymes and BER substrates have already demonstrated interplay between these BER enzymes that is sensitive to the...

In large mammals there is a correlation between microtubule network densification and contractile dysfunction in severe pressure-overload hypertrophy. In small mammals there is a similar correlation for the shift to beta-myosin heavy chain (MHC), a MHC isoform having a slower ATPase Vmax. In this study, murine left ventricular (LV) pressure overload invoked both mechanisms: microtubule network ...

We report the case of a 25-years-old male with beta-thalassemia major who developed acute heart failure, with severe systolic dysfunction, resulting from iron overload. Combined iron chelation with desferrioxamine and deferiprone together with standard cardiological treatment induced prompt and complete restoration of the cardiac function.