A systematic approach is described for analysis of evolutionarily conserved cis-regulatory DNA using cis-Decoder, a tool for discovery of conserved sequence elements that are shared between similarly regulated enhancers. Analysis of 2,086 conserved sequence blocks (CSBs), identified from 135 characterized enhancers, reveals most CSBs consist of shorter overlapping/adjacent elements that are eit...

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A complex service-based system (CSBS), which comprises a multi-layer structure possibly spanning multiple organizations, operates in a highly dynamic and heterogeneous environment. At run time the quality of service provided by a CSBS may suddenly change, so that violations of the Service Level Agreements (SLAs) established within and across the boundaries of organizations can occur. Hence, a k...

This paper describes the aging behavior of the oil impregnated repulped cellulose and compares it with the aging behavior of the oil impregnated standard cellulose. In order to evaluate the reliability of using repulped cellulose in transformers, the accelerated aging process was applied to both types of cellulose by increasing the temperature to 150 °C and their aging behavior was studied and ...

The Child Behavior Checklist 1.5–5 (CBCL 1.5–5) has been applied to identify emotional and behavioral problems on children with autism spectrum disorder (ASD). However, few studies explored whether the established factor model may be suitable for ASD those developmental delay (DD). To locate potential sources of variations between these two groups, we tested measurement invariance multiple grou...

OBJECTIVE The benefits of cochlear implantation for children with developmental delays (DD) often are unclear. We compared cognition, adaptive behavior, familial stress, and communication in children with and without DD. STUDY DESIGN Retrospective review. SETTING Two tertiary care pediatric hospitals. PATIENTS Two hundred four children who underwent cochlear implantation assessed before a...

Research suggests that depressive personality (DP) disorder may represent a persistent, trait-based form of depression that lies along an affective spectrum ranging from personality traits to diagnosable clinical disorders. A significant gap in this area of research concerns the development of DP and its applicability to youth. The present research explored the construct of DP traits in youth. ...

This study examined the stability of internalizing and externalizing problems from age 1.5 to 6 years, while taking into account developmental changes in the presentation of problems. The study comprised a population-based cohort of 7,206 children (50.4 % boys). At ages 1.5, 3, and 6 years, mothers reported on problem behavior using the Child Behavior Checklist/1.5-5 (CBCL/1.5-5). At each age w...

One of the consequences of genetic impairments in early childhood is their long-term effect on children's developmental skills in communication, learning, and adaptive behaviors. Functional assessment provides families and clinicians with a common language for describing a child's strengths and limitations in self-care (feeding, dressing, grooming, bathing, continence), mobility, and communicat...