Synergistic Therapy In article number 2101155, Yujun Song, Zhengbao Zha, Xin Han, and co-workers report a novel thermo-responsive nanotherapeutic platform, which is triggered by 808 nm near-infrared light irradiation. This exogenously controlled method can be used in combination tumor therapy, including gene-therapy, mild-photothermal chemotherapy, provides versatile strategy for gene editing d...

The current clinical application of combination chemotherapy is guided by a historically successful set of practices that were developed by basic and clinical researchers 50-60 years ago. Thus, in order to understand how emerging approaches to drug development might aid the creation of new therapeutic combinations, it is critical to understand the defining principles underlying classic combinat...

Objectives. Chemotherapy is considered to be essential in the treatment of patients with colorectal cancer (CRC), but drug resistance reduces its efficacy. Many advanced CRC eventually show 5-fluorouracil (5-FU) therapy. Synergistic and potentiating effects combination therapy, using herbal chemical drugs, can improve patients’ response. Zerumbone (ZER), which derived from ginger, has been stud...

Combination drug therapy is commonly used to treat cancer, diabetes, cardiovascular conditions, and infections. However, these therapies face challenges associated with patient compliance toxicology. Over the past decades, microdevices have emerged as a promising candidate for oral delivery allowing targeted tunable release. In present work, engineered monodisperse dual-compartment are develope...

We report a case of 15 year old female patient of xeroderma pigmentosum with large squamous cell carcinoma on the left side of cheek. She received combination chemotherapy with isotretinoin for a period of 4 months and showed complete clinical remission of tumour. The role of isotretinoin in cancer prevention and management of malignancies associated in xeroderma pigmentosum is also reviewed th...

s T n the last decade, continued efforts in pancreas cancer esearch have led to the development of new, more ffective therapies. Additionally, progress in understandng the molecular processes underlying the developent and progression of this disease provides hope for he development of more effective treatment strategies. ecent clinical trials have provided reason for hope that ovel chemotherapy...