This study aimed to investigate the expression and clinical significance of micro ribonucleic acid-132 sex-determining region Y-box 4 gene in colon cancer. Luciferase reporter system was used validate target directly regulated by acid-132. Transwell invasion assay test effect on invasiveness SW620 cells. Micro levels cancerous peri-cancerous tissues were measured using situ hybridization EleVis...

AIM To explore the relationship between colonic secretory function and colonic motility. METHODS Using a rat model chronically implanted with intracerebroventricular (ICV) and cecal catheters, we validated the correlation between colonic secretion and colonic motor functions, as well as the role of ICV injection volume. RESULTS Compared to saline controls (5 μL/rat), ICV acyl ghrelin at 1 n...

BACKGROUND Chronic constipation is one of the most common chronic disease in children. Most of cases are functional, however some has problem of organic myopathic or neuropathic colon. Colonic transit study with oro-anal transit markers is the basic diagnostic tool for colonic dysmotility in clinical practice, colonic manometry is the recommended investigation in the next step. Nevertheless, th...

Ilias Kouerinis, Kipselis 17, 11257 Athens, Greece, e-mail: [email protected] Conversely, several degrees of colonic lesions following pancreatic abscess formation have been described: a) localized paralytic ileus of the transverse colon b) Intramural involvement of the colon in a localized area c) colonic stricture simulating colonic carcinoma d) colonic bleeding e) colonic fistula. The i...

Approved angiogenesis inhibitors generally target certain growth factors or their receptors, which exist in both normal and cancerous cells; this results suppression of cell-signaling pathways throughout the body causes adverse effects. For reason, there is a need for new inhibitor that can specifically tumor vasculature. In our previous study, we revealed doppel, prion-like protein, was overex...

Polysaccharide-based carriers have become attractive materials for the delivery of therapeutics targeting colon. Ferulated arabinoxylans (AX)—polysaccharides with gelling and antioxidant capacities that can be degraded by colonic microbiota—are ideal candidates use as oral drug systems [1]. Recently, AX-based microspheres demonstrated potential applications colon-targeted [2,3]. The non-cytotox...

Background/Aims After exclusion of structural diseases, chronic constipation may be associated with normal or slow transit or rectal evacuation disorders. We evaluated: (1) clinical features and anorectal function, (2) difference of regional colonic transit according to the presence or absence of evacuation disorders, and (3) association of colonic transit with gender in patients with objective...

Enteric duplications are rare congenital anomalies found anywhere from mouth to anus. Colonic constitute about 13% of all enteric duplications. In this report a 6-year-old boy with chronic abdominal pain for duration last 2 years requiring intermittent hospital admissions was diagnosed as colonic duplication mimicking intestinal volvulus. Clinical findings nonspecific and definitive diagnosis c...

BACKGROUND Colonic atresia and stenosis are rare entities. On average 1 case per year of colonic atresia is being seen in most of pediatric surgical centers and to date less than 10 cases of colonic stenosis have been reported. MATERIAL AND METHODS The medical record of patients of colonic atresia and stenosis managed during March 2006 to March 2010 was reviewed. RESULTS A total of 15 patie...