The canonical route from normal tissue to cancer occurs through sequential acquisition of somatic mutations. Many studies have constructed a linear genetic model for tumorigenesis using the genetic alterations associated with samples at different stages of neoplastic progression from cross-sectional data. The common interpretation of these models is that they reflect the temporal order within a...

Adenocarcinoma as a cause of acute appendicitis is unusual, occurring in approximately 1.0% of all cases of appendicitis. Nevertheless, management of appendiceal adenocarcinoma as a routine appendicitis may have an adverse outcome for the patient. Iatrogenically, a contained malignant process may be converted into a disseminated disease that will have a lethal outcome. Staging of appendiceal ad...

INTRODUCTION Malignant neoplasm of the colon is one of the most common gastrointestinal cancers and takes the second place in terms of incidence in the world. In Asian countries compared with Western countries the incidence is a bit lower. In recent years in Poland there has been a disturbing increase in the incidence of this cancer, particularly in the voivodships Mazowieckie, Slaskie, and Wie...

Patients with megaesophagus (ME) have increased prevalence of cancer of the esophagus. In contrast, a higher incidence of colorectal cancer is not observed in patients with megacolon (MC). MC is very common in some regions of Brazil, where it is mainly associated with Chagas disease. We reviewed the pathology records of surgical specimens of all patients submitted for surgical resection of MC i...

BACKGROUND/AIMS The lifestyle changes that have accompanied economic growth have influenced disease patterns in Korea. Changing patterns of gastrointestinal (GI) diseases over the past two decades were investigated in the present study. METHODS Data from inpatients with specific GI diseases, as defined by the International Classification of Diseases code, were extracted from the database at a...

Purpose. To analyse perioperative and oncological outcomes of minimally invasive simultaneous resection of primary colorectal neoplasm with synchronous liver metastases. Methods. A Medline revision of the current published literature on laparoscopic and robotic-assisted combined colectomy with hepatectomy for synchronous liver metastatic colorectal neoplasm was performed until February 2015. Th...

A gastrointestinal stromal tumor (GIST) is a rare malignancy, accounting for only 0.1% to 3% of all (GI) malignancies. Although GISTs are the most common mesenchymal GI tract, they primarily found within stomach, with rectal rarely reported. They may present bleeding, constipation, pain, or palpable mass while some incidentally. The incidence has been on rise, possibly due advancements in diagn...

Aim: Sessile serrated lesions (SSL) have the potential for malignant transformation into colorectal carcinoma (CRC), which develops via pathway of carcinogenesis. Material and Methods: Based on colonoscopy pathology reports, all sessile or polyps in risk screening group were studied at an urban medical research center between July 2018 2022. We prospectively included consecutive classified as a...

stromal tumor that develops from gastro-intestinal (GI) mesenchymal cells from the esophagus to the rectum. Before 1990, most investigators thought these mesencgymal cell tumor to be the neoplasm from smooth muscle of gastrointestinal tract, and considered that these tumors were one kind of leiomyoma, leomyosarcoma or leiomyoblastoma. With the advent of immuno-chemical staining and ultra-struct...