Dystrophic epidermolysis bullosa, a severely disabling hereditary skin fragility disorder, is caused by mutations in the gene coding for collagen VII, a specialized adhesion component of the dermal-epidermal junction zone. Both recessive and dominant forms are known; the latter account for about 40% of cases. Patients with dominant dystrophic epidermolysis bullosa exhibit a spectrum of symptoms...

Collagen meshes with large or small openings were prepared after selective removal of PLGA mesh from PLGA–collagen composite collagen-coated mesh. The collagen support human skin fibroblast adhesion and promote cell proliferation.

Epidermolysis bullosa is a group of disorders whose common primary feature is the formation of blisters following trivial trauma. Recessive dystrophic epidermolysis bullosa (RDEB), a subtype of epidermolysis bullosa, is frequently associated with growth retardation. This growth retardation has been reported to be caused by trophopathy following protein loss through skin lesions. Endocrine disor...

TThis study investigated the water absorption of chitosan, collagen, and chitosan/collagen blend membranes exposed to gamma-ray irradiation. These membranes were produced via the solvent evaporation method. All membranes then underwent irradiation at 15 or 25 kGy gamma-ray doses, while membranes without irradiation were used as controls. After immersing the membranes in distilled water for up t...

Linear focal elastosis (LFE) is a disorder of elastic fibers characterized by palpable, yellow ish, linear striae distributed horizontally over the mid and lower back. Histologically, the find ings are increased amounts of elastic fibers with a fairly thin, wavy, elongated and fragmented morphology. The most important differential diagnosis of LFE is striae distensae which is mainly a disorder ...

Keloid disorder (KD) is a fibroproliferative ailment of the cutaneous connective tissue secondary to dysregulation in various skin repair and healing processes. This disorder is characterized by excess collagen and/or glycoprotein depositions in the dermis. Age of onset of KD is not well documented. Based on clinical observations, various authors have reported the onset of KD to be between the ...

introduction & objective: the brain choroids plexus (bcp) plays an important role in the cerebrospinal fluid (csf) production, but its characterization is still incomplete. collagen type iv, is one of the most important proteins of basement membrane (bm) and extracellular matrix (ecm) of bcp. in the present study we investigated the differential period of type iv collagen in basement membrane o...

nigella sativa (ns) ( ranunculaceae ) used as a protective and therapeutic traditional medicine. this study evaluates the effect of ns on inflammation-induced myocardial fibrosis, serum and tissue inflammatory markers, and oxidative stress status in male rats. fifty male wistar rats were divided into five groups: (1) control; (2) lipopolysaccharide (lps), 1 mg/kg/day; (3) lps + ns (hydroalcohol...