In 2017 I had the honor of meeting Steven Weinberg—whose obituary appears in October 2021 issue Physics Today (page 72)—at University Texas at Austin. past used some his writings from Scientific American and books for my students Wagner College, where taught honors lecture astronomy. often corresponded with 1994 to 2018 about concepts astrophysics, he answered many questions that submitted me.I...

Colchicine, a natural product of Colchicum autumnae currently used for gout treatment, is a tubulin targeting compound which inhibits microtubule formation by targeting fast dividing cells. This tubulin-targeting property has lead researchers to investigate the potential of colchicine and analogs as possible cancer therapies. One major study conducted on an analogue of allocolchicine, ZD 6126, ...

We have developed high-resolution methods for mapping nucleosomes, transcription factors (TFs) and their dynamics while minimizing disruption. 1) CUT&RUN (Cleavage Under Targets & Release Using Nuclease) is a chromatin profiling strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific protein-DNA complexes into the supernatant for paired-end DNA sequenci...

Colchicine, the major alkaloid of the meadow saffron, is one of the most prominent natural products and, like other tubulin-binding natural products (e.g. taxol and the epothilones), exhibits great pharmaceutical potential. The first syntheses in the late 1950s were milestones in natural product synthesis. But even today this structurally supposedly simple molecule poses a challenge to syntheti...

Global surface temperature is predicted to increase by at least 1.5°C by the end of this century. However, the response of soil microbial communities to global warming is still poorly understood, especially in high-elevation grasslands. We therefore conducted an experiment on three types of alpine grasslands on the Qinghai-Tibet Plateau to study the effect of experimental warming on abundance a...