Type 1 diabetes is associated with cognitive changes in children and adults, but the extent to which cognition declines with increasing age, and increasing duration of diabetes, remains poorly understood. This cross-sectional study assessed neuropsychological performance on 200 diabetic and 175 nondiabetic adults, 18-64 years of age, stratified into five age bands. Similar age-related cognitive...

fact, people are always in pursuit of diets that are effective and easy to follow. Studies show that the Dietary Approach to Stop Hypertension (DASH diet) and The Mediterranean diet are beneficial for weight loss, glycaemic control in diabetics, primary prevention in patients at high risk of cardiovascular disease, certain cancers, a decrease in the mortality rate and slower cognitive decline i...

OBJECTIVE To investigate the possible role of diet in age-related cognitive decline (ARCD) and cognitive impairment of both degenerative (Alzheimer's disease, AD) and vascular (vascular dementia, VaD) origin. DESIGN Literature review. RESULTS In an elderly population of southern Italy with a typical Mediterranean diet, high energy intake of monounsaturated fatty acids (MUFA) appeared to be ...

BACKGROUND Cognitive decline complicates early recovery after coronary-artery bypass grafting (CABG) and may be evident in as many as three quarters of patients at the time of discharge from the hospital and a third of patients after six months. We sought to determine the course of cognitive change during the five years after CABG and the effect of perioperative decline on long-term cognitive f...

Across a range of psychometric tests, reaction times slow as adult age increases. These changes have been widely taken to show that cognitive-processing capacities decline across the lifespan. Contrary to this, we suggest that slower responses are not a sign of processing deficits, but instead reflect a growing search problem, which escalates as learning increases the amount of information in m...

Cognitive decline following surgery in older individuals is a major clinical problem of uncertain mechanism; a similar cognitive decline also follows severe infection, chemotherapy, or trauma and is currently without effective therapy. A variety of mechanisms have been proposed, and exploring the role of inflammation, we recently reported the role of IL-1β in the hippocampus after surgery in mi...

In a prospective study among 4,409 subjects aged 65+ years, we assessed the relation of nonsteroidal anti-inflammatory agents (NSAIDs) to cognition. The main outcome was decline in global cognitive function, determined by average performance across four cognitive tests, over up to four interviews. We found similar rates of cognitive decline among recent users of aspirin and of other NSAIDs (lar...