Treatment of hypercholesterolemia with statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) is effective in the primary and secondary prevention of cardiovascular disease. However, statin use is often associated with a variety of muscle-related symptoms or myopathies. Myopathy may be related in part to statin inhibition of the endogenous synthesis of coenzyme Q10, an essential c...

The partial mitotic inhibition caused by 6-mercaptopurine in tissue cultures of Crocker mouse sarcoma 180 and embryonic mouse skin is blocked by co-enzyme A. 6-Mercaptopurine and coenzyme A also have opposite effects on mitochondrial morphology. Mitochondria in cells treated with 6-mercaptopurine become thin and fragmented. Coenzyme A blocks this effect, and alone coenzyme A makes for longer an...

BACKGROUND It has been reported that higher levels of oxidative stress and inflammation play a key role in the progression of hepatocellular carcinoma (HCC) after surgery. Coenzyme Q10 is an endogenous lipid-soluble antioxidant. To date, no intervention study has investigated coenzyme Q10 supplementation in HCC patients after surgery. The purpose of this study was to investigate oxidative stres...

OBJECTIVES This study evaluated the effects of oral therapy with coenzyme Q on echocardiographic and hemodynamic indexes of left ventricular function and on quality of life in patients with chronic left ventricular dysfunction. BACKGROUND Coenzyme Q is a coenzyme for oxidative phosphorylation and an antioxidant and free radical scavenger. It has been claimed to improve symptoms, quality of li...

An important r81e for pantothenic acid in carbohydrate metabolism was suggested by studies in which pantothenic acid-deficient bacteria (1, 2) and liver (3) were observed to utilize pyruvate at rates much less than normal. The subsequent discovery of Lipmann and his colleagues that the coenzyme of acetylation (coenzyme A) (4) contained pantothenic acid (5) provided a stimulus for the reinvestig...

The first step of anaerobic benzoate degradation is the formation of benzoyl-coenzyme A by benzoate-coenzyme A ligase. This enzyme, purified from Rhodopseudomonas palustris, is maximally active with 5 microM benzoate. To study the molecular basis for this reaction, the benzoate-coenzyme A ligase gene (badA) was cloned and sequenced. The deduced amino acid sequence of badA showed substantial sim...

Article history: Received: .................. Accepted: ................... Available online: ........ ZJRMS 2015 Sep; X(X): XX-XX Background: Heavy exercise cause muscle damage associated with very-high production of free radicals. The aim of this research was to evaluate the effect of acute and 14-day coenzyme Q10 supplementation on oxidative stress and muscle damage indicator in elite male m...

Purified preparations of the reduced nicotinamide adenine dinucleotide dehydrogenase of the respiratory chain, extracted with the aid of phospholipase at moderate temperature, do not catalyze the reduction of long chain coenzyme Q derivatives (Q6 and QIO) at significant rates and are not inhibited by amytal or rotenone. On exposure of the enzyme to conditions which have been used for the extrac...

4. CRANE, F. L., LESTER, R. L., WIDMER, C. and HATEFI, Y. Studies on the electron transport system XVIII. Isolation of coenzyme Q from beef heart and beef heart mitochondria. Biochim. Biophys. Acta 32: 73-79. 1959. 5. CRANE, F. L., WIDMER, C., LESTER, R. L. and HATEFI, Y. Studies on the electron transport system XV. Coenzyme Q (Q275) and the succinoxidase activity of the electron transport part...