Coeliac disease in children and adults is considered to be a variety of the same disorder. This gains epidemiological support in the present study, which reports on the observed prevalence of coeliac disease in an area of Sweden (population, 140 500). On 1 July 1981, the prevalence rate was found to be 104/100 000 (1:960) among children, and the same figure, 106/00 000 (1:950), was found for co...

We appreciated the paper by Levy et al published in this journal in June 2003. A number of the cases of chronic urticaria in children appear to be of unknown aetiology, and experiences such as the one reported by the authors indicate an autoimmune origin. In our opinion the model of association between thyroiditis and chronic urticaria may apply to the association between coeliac disease and ch...

Coeliac disease is a chronic inflammatory disease of the gut with increased risk of gastrointestinal malignancy. Although enteropathy T-lymphoma is the most common neoplasm in patient affected by coeliac disease, an increased frequency of small bowel carcinoma has been described. We present a case of jejunal carcinoma in a patient suffering for coeliac disease in which gastrointestinal and extr...

BACKGROUND Tissue transglutaminase is now recognized as the autoantigen for antiendomysial antibodies. Antibodies to tissue transglutaminase have been proposed as a valuable test for coeliac disease. OBJECTIVE To determine the value of antibodies to tissue transglutaminase in the diagnosis of coeliac disease in our outpatient population. METHODS Patients who underwent serological tests for ...

Intestinal biopsies were performed in children suffering from coeliac and other diseases and were stained by the 'astra-blau' method for visualising granulated mast cells. The density of granulated mast cells (per microscopical field) in treated coeliac disease and in 3 control groups (patients suffering from milk allergy, failure to thrive, or protracted diarrhoea) was 15--18 cells per microsc...

and coeliac disease: an association? Lancet 1984;2:13–15. 10 Anon. Sarcoidosis and coeliac disease. Lancet 1984;2:408. 11 Lowe G, Johnston RN. Sarcoidosis and coeliac disease. Lancet 1984;2:637. 12 Rutherford RM, Brutsche MH, Kearns M, et al. Prevalence of coeliac disease in patients with sarcoidosis. Eur J Gastroenterol Hepatol 2004;16:911–15. 13 Zasloff M. Fighting infections with vitamin D. ...

BACKGROUND To describe the presenting clinical features of coeliac disease in a single paediatric centre, and to determine if the presenting features vary with age. METHODS A review was conducted of children who had been referred with clinical suspicion of coeliac disease to the paediatric gastroenterology department of a tertiary paediatric hospital in Sydney, Australia. Coeliac disease was ...

Coeliac disease has a significant association with many autoimmune disorders. It shares many common genetic and immunological features with other autoimmune diseases. Gluten, a gut-derived antigen, is the driver of the autoimmunity seen in coeliac disease. The altered intestinal permeability found in coeliac patients, coupled with a genetic predisposition and altered immunological response, may...

In a series of 46 children with untreated coeliac disease and in 102 controls with normal mucosa the 1-hour blood-xylose test was, in view of its simplicity, of much value in the diagnosis of childhood coeliac disease. Only one blood-xylose result was falsely normal in the 46 coeliac patients. It is concluded that a normal blood-xylose value does not exclude coeliac disease and should not prev...