The role of complement during the invasion of red blood cells by Plasmodiummerozoites is an enticingfield of study that has great potential to impact not just our overall understanding of how the parasite interacts with the human host but also guide future efforts in the development of efficacious malarial vaccines. The complexity of parasite and host interactions during the invasion of red blo...

Earlier work by the author and coworkers (Adams & Whittaker, 1948; Adams, 1949; Whittaker, 1949; Mounter & Whittaker, 1950; Mounter, 1951) has shown that the so-called 'true' or 'specific' cholinesterases of erythrocytes, brain and cobra venom, previously believed to act only on acetylcholine and a few other esters, are in reality capable of hydrolysing a wide range of non-choline esters, 3:3-d...

Although Chinese cobra snakebite is the most common type of snake venenation in China, it still lacks a comprehensive and systematic description. Hence, we aimed to study Chinese cobra bite cases with particular attention to demography, epidemiology and clinical profile. In this study, a total of 292 cases of Chinese cobra snakebite, presenting between January 1, 2008 and December 31, 2012, wer...

Lipide extracts of the red cells of several animal species have been analyzed chromatographically. Genetically determined differences in phospholipide composition were found. Lecithin is absent from the cells of ox, sheep, and goat. Cells containing lecithin are susceptible to the direct hemolysin of cobra venom while cells not containing lecithin are resistant. The facts indicate that the dire...

Immunoglobulin G in human serum neutralizes chlamydial infectivity in vitro. Complement-intact, C5-depleted, and C8-depleted human serum all have significantly more neutralizing activity than serum heated to inactivate early components of complement. Cobra venom factor, an analog of human C3b, enhances neutralization of antichlamydial immunoglobulin G in the absence of early complement components.

We report the development of molecularly imprinted polyacrylamide nanoparticles that bind to and neutralize the activity of cytotoxins present in the venom of the Mozambique Spitting Cobra (Naja mossambica mossambica). The binding activity of these nanoparticles is avid and specific. These findings hold promise for the development of a synthetic antivenom.

PURPOSE To investigate synergistic suppression of donor liver pre-perfusion with recipient serum (RS) and cobra venom factor (CVF) treatment on hyperacute rejection (HAR) following liver xenotransplantation. METHODS Guinea-pigs (GP, n=24) and Sprague-Dawley rats (SD, n=24) were recruited. Before transplantation, serum was collected from SD rats and used for preparation of inactivated compleme...

To the Editor, " Indian Medical Gazette." Sir,?Iu reply to Dr. Ashmead's enquiry in the November number of the Indian Medical Gazette, I may relate the following : ? In July last, I took a pariah dog, chloroformed him and exposed a vein on the inside of the thigh When he had recovered from the chloroform a monocellate cobra was made to bite his fore paw. The snake was promptly killed and as muc...

The photodynamic action of UV sensitized methylene blue (MB) was studied on the venom of Thailand cobra Naja siamensis. The reaction mixture comprising phosphate buffer (B), methylene blue (S), and venom protein (P) was exposed to UVR (ultra violet radiation) for 2 hours at 37°C. Stable excited species (S’) were generated by photodynamic action. These in B environment produced reduced substates...

The role of complement in host resistance to infection with Trypanosoma musculi was studied in normal, C5-deficient, and C3-depleted mice. Infections in normocomplementemic strains (CBA and B10.D2/n) were generally similar to those in strains genetically deficient in C5 (A and B10.D2/o). There were no differences in inhibition of reproduction, duration of infection, persistence of parasites in ...