The receptor for Factor VIII/von Willebrand factor (F. VIIIVWF) is readily available on circulating platelets. We have found that the stimulation of platelets with traces of thrombin at concentrations that are generated physiologically (0.008 U-0.05 U/ml) induced concentration-dependent binding of 125I-labeled F. VIIIVWF in a steady-state system. The binding induced by thrombin was specific bec...

A B ST R A CT The receptor for Factor VIII/von Willebrand factor (F. VIIIVwF) is not readily available on circulating platelets. We have found that the stimulation of platelets with traces of thrombin at concentrations that are generated physiologically (0.008 U0.05 U/ml) induced concentration-dependent binding of '251-labeled F. VIIIvwF in a steady-state system. The binding induced by thrombin...

Neuroserpin is a serine protease inhibitor of the serpin family that has been identified as an axonally secreted glycoprotein in neuronal cultures of chicken dorsal root ganglia. To obtain an indication for possible functions of neuroserpin, we analyzed its expression in the developing and the adult CNS of the mouse. In the adult CNS, neuroserpin was most strongly expressed in the neocortex, th...

Rapid neurite remodeling is fundamental to nervous system development and plasticity. It involves neurite extension that is regulated by NGF through PI3K/AKT, p44/42 MAPK and p38 MAPK. It also involves neurite retraction that is regulated by the serine protease, thrombin. However, the intracellular signaling pathway by which thrombin causes neurite retraction is unknown. Using the PC12 neuronal...

The human melanoma cell line M24met expresses tissue factor, the cellular initiator of the blood coagulation cascade. Blocking of the coagulation pathways at the level of tissue factor, factor Xa, or thrombin inhibits hematogenous M24met metastasis in SCID mice, implicating a role for thrombin generation in this process. Dependent on cell surface tissue factor activity, M24met cells generate th...

Venous and arterial thromboembolic diseases are still the most frequent causes of death and disability in high-income countries. Clinical anticoagulants are inhibitors of enzymes involved in the coagulation pathway, such as thrombin and factor X(a). Thrombin is a key enzyme of blood coagulation system, activating the platelets, converting the fibrinogen to the fibrin net, and amplifying its sel...

how to cite this article: aghayan golkashani h, hatami h, farzan a, mohammadi hr, nilipour y, khoddami m, jadali f. tumors of the central nervous system: an 18-year retrospective review in a tertiary pediatric referral center. iran j child neurol. summer 2015;9(3):24-33.   abstract objective few studies exist on the demographics and trends of pediatric central nervous system (cns) tumors in ira...

introduction: burkitt lymphoma (bl) is rare, but an aggressive malignancy. central nervous system burkitt lymphoma (cnsbl) is very rare. cns burkitt’s lymphoma is treated with high-dose chemotherapy and radiation. radiotherapy in children younger than three years old may cause major cns damage. case report: a three-year-old boy presented with painful proptosis of the left eye. he underwent aden...