The physiology and the pathology of Central Nervous System (CNS) is very complex, only by understanding it scientific research might develop effective treatments. Neurocognitive Disorders, extremely diffused diseases, have a multifactorial aetiology, in which lipid homeostasis plays an important role, as known. aim this mini-review focus on interesting recently published researches topic, order...

Prion diseases, which can manifest by transmissible, sporadic or genetic etiologies, share several common features, such as a fatal neurodegenerative outcome and the aberrant accumulation of proteinase K (PK)-resistant PrP forms in the CNS. In infectious prion diseases, such as scrapie in mice, prions first replicate in immune organs, then invade the CNS via ascending peripheral tracts, finally...

tumors of the central nervous system (cns), occur relatively frequently during the early years of life. they are the most common solid tumors of childhood and are second only to leukemia in overall cancer incidence and account for a high proportion of deaths. in different studied performed in several countries, astrocytomas and other gilomas (combined) account for half of the cns malignancies, ...

Astrocytes regulate fundamentally important functions to maintain central nervous system (CNS) homeostasis. Altered astrocytic function is now recognized as a primary contributing factor to an increasing number of neurological diseases. In this review, we provide an overview of our rapidly developing understanding of the basal and inflammatory functions of astrocytes as mediators of CNS respons...

Objective(s): Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are regarded as autoimmune diseases of the central nervous system (CNS).  The CNS, testes, and eyes are immune privileged sites.  It was initially presumed that ocular involvement in EAE and infertility in MS are neural-mediated.  However, inflammatory molecules...

Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) disease are two demyelinating diseases of the central nervous system (CNS) that serve as animal models for multiple sclerosis. Th1 cells are thought to play a role in the pathogenesis of CNS demyelination in both these diseases. We show here the differential influence of interleukin 12, a critical ...

background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...

The last 15 years have seen an explosion of new findings on the role complement, a major arm immune system, in central nervous system (CNS) compartment including contributions to cell migration, elimination synapse during development, aberrant pruning neurologic disorders, damage nerve cells autoimmune diseases, and traumatic injury. Activation complement multiple sclerosis (MS) is typically th...

The repair of central nervous system (CNS) disorders, such as Parkinson's disease (PD) and spinal cord injury, is difficult. Neural stem cells (NSCs) transplantation is believed to be effective in the treatment of neural diseases [1] , however, NSCs are limited and difficult to be isolated from brain. Bone marrow mesenchymal stem cells (BMSCs) are a new cell source to CNS diseases for the cells...

Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood-brain barrier and the blood-cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficien...