Background: Opioid abuse is common in Iran. In recent years, methadone maintenance therapy (MMT) has gained popularity in this country. This study aimed at evaluation concurrent abuse of alcohol in patients under MMT. Methods: A predesigned questionnaire was developed and completed after obtaining verbal consent among 49 subjects under MMT in Kian Rehabilitation Centre during January 2014. Resu...

We are grateful to Dr Ronald Wood for providing in his letter in the July issue (Wood 2005) his expert views and methodologies that could potentially be used in future to test the behavioural effects of airborne contaminants and irritants. Dr Wood seems to accept in his letter that carbon dioxide is aversive but he is unsure how aversive, and believes that it can be safely and humanely used in ...

background: opioid abuse is common in iran. in recent years, methadone maintenance therapy (mmt) has gained popularity in this country. this study aimed at evaluation concurrent abuse of alcohol in patients under mmt. methods: a predesigned questionnaire was developed and completed after obtaining verbal consent among 49 subjects under mmt in kian rehabilitation centre during january 2014. resu...

BACKGROUND Ventilator-Associated Pneumonia (VAP) is the main cause of nosocomial infection at intensive care units (ICUs), which causes high mortality and morbidity. OBJECTIVES The objective of the present survey was to identify the VAP risk and prognostic factors among poisoned patients, who were admitted to the toxicological ICU (TICU), especially central nervous system (CNS) depressants du...

Lurasidone [(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel antipsychotic candidate. The objective of the current studies was to investigate the in vitro and in vivo pharmacological properties of lurasidone. Receptor binding affinities of lu...

E. Neriifolia is an herb extensively used in the Indian system of medicine, is a small deciduous tree of the family Euphorbiaceae. As traditional medicine the plant is useful in abdominal troubles, bronchitis, tumors, leucoderma, piles, inflammation, enlargement of spleen, anemia, ulcers, fever and in chronic respiratory troubles. E. neriifolia predominantly contains sugar, tannins, flavonoids,...

There exist a large number of drugs belonging to the benzodiazepine family. These include the 1,4-benzodiazepines such as diazepam, temazepam and oxazepam, the often more potent diazolo- and triazolo-groups represented by alprazolam, midazolam, triazolam etc. These drugs represent a large range of potencies from submilligram doses to over 100 mg and a range of polarities. Consequently, blood or...

Dioscorea bulbifera commonly known as Varahikanda, is widely distributed throughout the India, and it has been traditionally used for the treatment of nervous excitability, senility and hysteria. Based on this, neuropharmacological activity of tubers of D. bulbifera was evaluated using various experimental models. Effects of hydroalcoholic extract of Dioscorea bulbifera tubers (DBE) (10,30,100,...

Objective: Valeriana (V) wallichii DC is found among the ground flora of Himalayan regions and used as herbal medicine for CNS disorders in Indian systems medicine. In study, aimed to investigation involvement neuro-chemical-systems V. induced antidepressant effects mice.
 Methods: The activity aqueous alcoholic extracts was measured by using Forced Swim Test Tail Suspension mice, whereas ...