The process of human blood clotting involves a complex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenomena, where the former comprise the various chemical rate equations and the latter comprise both thresholdlimited behaviors and binary states (presence/absence of a chemical). Whereas previous blood-clotting models used only continuous dynamics ...

Objective. The aim of this study was to identify routinely available clinical surrogate markers for potential clotting factor alterations following multiple trauma. Methods. In 68 patients admitted directly from the scene of the accident, all soluble clotting factors were analyzed and clinical data was collected prospectively. Ten healthy subjects served as control group. Results. Patients show...

We have studied factor VII activation by measuring the ratio of factor VII clotting to coupled amidolytic activity (VIIc/VIIam) and cleavage of 125I-factor VII. In purified systems, a low concentration of Xa or a higher concentration of IXa rapidly activated 125I-factor VII, yielding a VIIc/VIIam ratio of 25 and similar gel profiles of heavy and light chain peaks of VIIa. On further incubation,...

This article demonstrates that the rate of mixing can regulate the rate and outcome of both biological and nonbiological autocatalytic reaction systems that display a threshold response to the concentration of an activator. Plug-based microfluidics was used to control the timing of reactions, the rate of mixing, and surface chemistry in blood clotting and its chemical model. Initiation of clott...

Tissue factor (TF), the initiator of coagulation, continuously circulates in the plasma, and the clotting system “idles,” generating very low levels of active clotting enzymes, clotting products, and by-products. Given the enormous amplification potential of the clotting cascade, rigorous control is required to ensure that such low-level stimulation does not cause massive system amplification a...

The normal Gauss map of a minimal surface in the model space Sol of solvegeometry is a harmonic map with respect to a certain singular Riemannian metric on the extended complex plane.

The visible symmetric L-groups are a refinement of the symmetric L-groups of Mishchenko [12] and Ranicki [15]. They are much easier to compute, although they hardly differ from the symmetric L-groups in their formal properties. Cappell and Shaneson [3] use the visible symmetric L-groups in studying 4-dimensional s-cobordisms; see also Kwasik and Schultz [8]. The visible symmetric L-groups are r...

Eight male Holstein calves 7 to 10 d of age were fed a milk replacer containing a skim milk powder subjected to low-temperature drying either with or without addition of an oxalate-NaOH buffer known to prevent curd formation. The calves were used in a completely randomized design to study the effect of milk clotting on digestibility and blood parameters. Plasma glucose and plasma insulin were s...

Tissue factor (TF), the initiator of coagulation, continuously circulates in the plasma, and the clotting system “idles,” generating very low levels of active clotting enzymes, clotting products, and by-products. Given the enormous amplification potential of the clotting cascade, rigorous control is required to ensure that such low-level stimulation does not cause massive system amplification a...