Chitosan nanoparticles (NPs) decorated with adenosine diphosphate (ADP) (ANPs) or fibrinogen (FNPs) were used to fabricate hemostatic NPs that can shorten blood clotting time and prevent severe local hemorrhage. The structure and mechanical properties of the blood clot induced with ANP (clot/ANP) or FNP (clot/FNP) were also investigated. The NPs, ANPs, and FNPs, which had particle sizes of 245....

PURPOSE Rapid revascularization in emergent large vessel occlusion with endovascular embolectomy has proven clinical benefit. We sought to measure device-clot interaction as a potential mechanism for efficient embolectomy. METHODS Two different radiopaque clot models were injected to create a middle cerebral artery occlusion in a patient-specific vascular phantom. A radiopaque stent retriever...

The present study aims to conduct a quantitative evaluation of evacuation route safety using the Ant Colony Optimization (ACO) algorithm for risk management in central Tokyo. Firstly, the similarity in safety was focused on while taking into consideration road blockage probability. Then, by classifying roads by means of the hierarchical cluster analysis, the congestion rates of evacuation route...

5 Evacuation planning and scheduling is a critical aspect of disaster management and national security applications. This paper proposes a conflict-based path-generation approach for evacuation planning. Its key idea is to decompose the evacuation planning problem into a master and a subproblem. The subproblem generates new evacuation paths for each evacuated area, while the master problem opti...

In this paper, we consider the route coordination problem in emergency evacuation of large smart buildings. The building evacuation time is crucial in saving lives in emergency situations caused by imminent natural or man-made threats and disasters. Conventional approaches to evacuation route coordination are static and predefined. They rely on evacuation plans present only at a limited number ...

Road transportation networks are a segment of society’s critical infrastructure particularly susceptible to service disruptions. Traffic incidents disrupt road networks by producing blockages and increasing travel times, creating significant impacts during emergency events such as evacuations. For this reason, it is extremely important to incorporate traffic incidents in evacuation planning mod...

Emergencies, especially major ones, happen fast, randomly, as well as unpredictably, and generally will bring great harm to people's life and the economy. Therefore, governments and lots of professionals devote themselves to taking effective measures and providing optimal evacuation plans. This paper establishes two different emergency evacuation models on the basis of the maximum flow model (M...

The viscoelastic properties of blood clot have been studied most commonly using thrombelastography (TEG) and thromboelastometry (ROTEM). ROTEM-based bleeding treatment algorithms recommend administering platelets to patients with low EXTEM clot strength (e.g., clot amplitude at 10 minutes [A10] <40 mm) once clot strength of the ROTEM® fibrin-based test (FIBTEM) is corrected. Algorithms based on...

Evacuation route planning is one of the most crucial tasks for solving massive evacuation problem. In large public places, pedestrians should be transferred to safe areas when nature or man-made accidents happen. A multi-objective ant colony algorithm for massive pedestrian evacuation is presented in this paper. In the algorithm, three objectives, total evacuation time of all evacuees, total ro...