To elucidate carcinogenesis in the endometrium, we investigated cyclin D1 immunoreactivities in 20 normal endometria, 20 endometrial hyperplasias and 141 endometrioid-type endometrial adenocarcinoma. We also evaluated the correlation of cyclin D1 expression with Ki-67, cyclin E, cyclin A, cdk2, p27 and p53, and clinicopathological parameters and prognosis. Cyclin D1 expression increased signifi...

BACKGROUND Previous studies have been inconsistent with respect to the reported associations between human epidermal growth factor receptor (HER-2/neu) overexpression in colorectal cancer. The aims of this meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in colorectal cancer. METHODS Eligible studies were searched in Pubmed, Emba...

Although patients with gallbladder papillary adenocarcinoma (GBPA) appear to have better prognoses than patients with other pathological subtypes of gallbladder carcinoma (GBC), the clinicopathological features and outcomes of GBPA have not been fully explored. This study therefore analyzed the clinicopathological characteristics and outcomes of GBPA.This study included 16 patients with GBPA an...

BACKGROUND Atypical adenomatous hyperplasia (AAH) of the lung is a putative precursor lesion of adenocarcinoma, according to many immunohistochemical and genetical studies, but few clinicopathological studies on a large number of cases have been reported. The aim of this study was to clarify the clinicopathological characteristics of lung cancer patients with AAH lesions. METHODS A retrospect...

Background: The BRAF mutation is the most common genetic alteration in papillary thyroid carcinoma (PTC). In recent studies, the BRAF mutation has been associated with poor clinicopathological characteristics, such as lymph node metastasis, extrathyroidal extension, and advanced stage. However, other studies have failed to establish an association between the BRAF mutation and clinicopathologic...

Purpose: K-ras mutations were reported to be in 40% 60% of patients with sporadic colorectal cancers (CRCs). HER-2/neu oncogene that is important in breast carcinoma was reported in CRCs in several studies. The aims of our study are to determine; the frequency of K-ras mutation in CRC and positivity of HER-2/neu, the relation between K-ras mutation and HER-2/neu positivity, and also the relatio...

BACKGROUND/AIMS Epithelial-mesenchymal transition (EMT)-related proteins may exhibit differential expression in intestinal type or pancreatobiliary type ampulla of Vater carcinomas (AVCs). We evaluated the expression of E-cadherin, β-catenin, and S100A4 in intestinal and nonintestinal type AVCs and analyzed their relationships with clinicopathological variables and survival. METHODS A clinico...

BACKGROUND/AIMS Although LIN28A is known to potentially play a role in the oncogenesis of various cancers, whether LIN28A expression is a predictor of poor prognosis in patients with gastric cancer has not been fully explored. We sought to evaluate clinicopathological characteristics according to the expression of LIN28A in numerous gastric cancer tissue samples. METHODS LIN28A expression was...

haracteristics were compared among Cronartium quercuzzm f. sp . densiflorae and C. quercuum f. sp, thurzbergii from Japan ami C. quercuum f.sp. fusifomze, fusiform rust from the USA. We examined the PCR-amplifield internal transcribed spacer (ITS) regions of ribosomal DNA from Japanese and American sources of aeciospores by restriction fragment length polymorphism (RFLP) analysis and nucleotide...

Planning the capacity of a CCS system requires that a series of steps be followed in a systematic way. This chapter starts by providing a clear deenition of what adequate capacity means. It then presents a methodology that leads the capacity planner, in a step-by-step fashion, through the process of determining the most cost-eeective system connguration and networking topology. Investment and p...