OBJECTIVE Exposure to organophosphates (OP) may lead to a life threatening cholinergic crisis with death attributed to a rapidly progressive respiratory failure. In a toxicological mass casualty event involving organophosphate exposure, many of the victims may depend on immediate short-term ventilation to overcome the respiratory distress which may exhaust life supporting resources. In addition...

BACKGROUND Paraoxonase-1, an organophosphorous-hydrolyzing enzyme, was shown to provide protection against organophosphates poisoning in vivo. In vitro findings suggest that the phytoalexin resveratrol can elevate paraoxonase-1 levels and thus may provide protection against organophosphate poisoning. This study was conducted to evaluate the effect of prolonged resveratrol intake on paraoxonase-...

Acute organophosphate (OP) poisoning is one of the most common poisonings in emergency medicine and toxicological practice in some of the less-developed nations in South Asia. Traditionally, OP poisoning comes under the domain of emergency physicians, internists, intensivists, and toxicologists. However, some of the complications following OP poisoning are neurological and involve neurologists....

(CWP) in the USA over the last 30 years. They then state, ‘Similar trends have been noted in Europe’. We would like to expand on this statement in respect of our experience here in the UK. In the UK coal mining industry, health surveillance (by chest X-ray) has been provided, over the last four decades, initially at 5 year, and since 1974, 4 year intervals. The prevalence of CWP among employed ...

The distinction between true and suspected poisoning in children has not been made clear in previous work on childhood poisoning. A study of suspected poisoning in children under 15 years of age in a defined population of North East Bristol from November 1970 to July 1973 carried out by the Health Education Council Medical Research Division included 53,000 child-years at risk. The number of sus...

Background: It is becoming apparent that although inhibition of cholinesterase plays a key role in organophosphate (OP) toxicity, other factors are also important. One of the contributing factors for severity of OP poisoning is electrolyte imbalances such as hypokalemia. This study was aimed at evaluating the value of hypokalemia in association with plasma cholinesterase (PChE) levels in predic...

background:organophosphates are commercially available agrochemicals for pest control, but may be abused for deliberate self-poisoning. we report a case of suicidal ingestion of dimethoate, a moderately toxic organophosphate insecticide, which can cause refractory hemodynamic instability, and the successful use of methylene blue (mb) for counteracting this complication. case presentation: an un...

background: the effective therapeutic dose of pralidoxime methylsulphate for organophosphate (op) poisoning is necessary to be clarified. this study was designed to comparatively assess the blood level of pralidoxime (bpl) and clinical outcomes in op poisoned patients treated with intermittent dosing and patients treated with continuous infusion. methods: this was a prospective, open labelled, ...