The 10(th) December 2010 marked a new beginning for Regulation (EC) no. 1272/2008 on the classification, labelling and packaging of substances and mixtures (CLP) in Ireland with the start of its operational phase. It was on this date that the administrative and enforcement provisions for CLP were encompassed in the new Chemicals Amendment Act, 2010. In this Act, the Health and Safety Authority,...

Using a new mathematical model to analyze a detailed set of viral load data collected from ve infected patients after the administration of a potent inhibitor of HIV-1 protease, it was estimated that productively infected cells have, on average, a lifespan of 2.2 days (t1=2 = 1:6 days) and that plasma virions have a mean lifespan of 0.3 days (t1=2 = 0:24 days). The average total HIV-1 productio...

This aim of the study was to investigate the effect of CYP1A2 gene polymorphism on the metabolism of theophylline in minority and Han nationality. A total of 50 cases of Han (Han group) and 50 minority nationalities (ethnic groups) treated with theophylline were selected for the study. The genotype and allele frequencies of the two groups of CYP1A2 gene, G-3113A and G-3860A, were compared to de...

We compared creatinine clearances determined by enzymatic (Kodak Ektachem 700 single-slide, Boehringer Mannheim creatinine PAP) and nonenzymatic (Jaffé, HPLC) methods with glomerular filtration rate measured by inulin clearance in patients with varying degrees of renal function. The Kodak enzymatic assay gave values for creatinine 2 to 3 mg/L higher than the other methods. This resulted in sign...

Elucidation of the rate-determining process in the overall hepatic elimination of drugs is critical for predicting their intrinsic hepatic clearance and the impact of variation of sequestration clearance on their systemic concentration. The present study investigated the rate-determining process in the overall hepatic elimination of the HMG-CoA reductase inhibitors pravastatin, pitavastatin, at...

Chantler, C., and Barratt. T. M. (1972). Archives of Disease in Childhood, 47, 613. Estimation of glomerular filtration rate from plasma clearance of 51-chromium edetic acid. The glomerular filtration rate was estimated by a single compartment analysis of the rate of fall of plasma concentration of 51-chromium edetic acid after a single intravenous injection. This slope clearance consistently o...

The radlicsGdium clearance technic was used to measure the effect of Priscoline given intraarterially on the effective blood flowin muscle and skin of normal subjects and patients with periplheral vascular disease. The only clinically significant increase in the clearance rate of radiosodium (Na24) occurred in the skin; the clearance rate in muscle show-ed small increases which were constantly ...

The clearance rate of liposomal drugs from the circulation is determined by the rate and extent of both drug release and uptake of liposomes by cells of the mononuclear phagocyte system (MPS). Intravenously injected liposomes initially come into contact with serum proteins. The interaction of liposomes with serum proteins is thought to play a critical role in the liposome clearance. Therefore, ...