An efficient computational algorithm is developed to design microRNA-based synthetic cell classifiers and to optimize their performance.

While “agricultural and rural development” is one of the key policy areas, there is no universally accepted way on how to classify the urban and rural. On one hand, dissatisfied with the OECD approach in which a “rural area” is defined merely based on the population density, there has been a rich literature in the statistical discourse and policy debate on what other variables should be conside...

Multiple Instance Learning is concerned with learning from sets (bags) of feature vectors (instances), where the bags are labeled, but the instances are not. One of the ways to classify bags is using a (dis)similarity space, where each bag is represented by its dissimilarities to certain prototypes, such as bags or instances from the training set. The instance-based representation preserves the...

K e y w o r d s C o m p u t a t i o n a l physics, Parallel modelling and simulation, Cellular automata, Complex systems, Laser physics. 1. I N T R O D U C T I O N Laser dynamics has been t rad i t iona l ly analyzed by solving a set of coupled differential rate equat ions which describe the in terre la t ionships and t r ans i t ion rates among the electronic states in the laser active m e d i...

When a software system critical for an organization exhibits a problem during its operation, it is relevant to fix it in a short period of time, to avoid serious economical losses. The problem is therefore noticed to the organization having in charge the maintenance, and it should be correctly and quickly dispatched to the right maintenance team. We propose to automatically classify incoming ma...

CAM lesions are now seen as a significant pathology that could cause osteoarthritis of the hip joint. Currently there is no gold standard for classifying these lesions. We aim to show a simple method for classifying these lesions based on shape and position. Using CT 3D reconstruction, 91 preoperative CT scans from patients who had undergone hip arthroscopy for femoroacetabular impingement, wer...

Background: Expression of the HIV-1 vpr gene in human and fission yeast cells displays multiple highly conserved activities, which include induction of cell cycle G2 arrest and cell death. We have previously characterized a yeast heat shock protein 16 (Hsp16) that suppresses the Vpr activities when it is overproduced in fission yeast. Similar suppressive effects were observed when the fission y...

This paper presents a critical analysis of classification criteria for collaborative systems, and a more refined proposal for their reformulation. The analysis highlights the multiplicity of definitions and uses of the same set of classification terms which denote time relationships in collaborative systems. We observe that authors, when characterizing collaborative systems, use concepts withou...

Results We propose a clinically-oriented definition: “autoinflammatory diseases are diseases with clinical signs of inflammation, associated with elevated acute phase reactants and due to a dysfunction in the innate immune system, genetically determined or triggered by an endogenous factor”. It is hard to find natural properties able to underlie a useful classification of autoinflammatory disea...

This paper addresses the problem of classifying observations when features are context-sensitive, specifically when the testing set involves a context that is different from the training set. The paper begins with a precise definition of the problem, then general strategies are presented for enhancing the performance of classification algorithms on this type of problem. These strategies are tes...