The use of Pt(IV) complexes as pro-drugs that are activated by intracellular reduction is a widely investigated approach to overcome the limitations of Pt(II) anticancer agents. A series of ten mono- and bis-carboxylated Pt(IV) complexes with axial indole-3-acetic acid (IAA) and indole-3-propionic acid (IPA) ligands were synthesized and characterized by elemental analysis, ESI-MS, FT-IR, (1)H a...

Quantum chemistry is a useful tool in modern approaches to drug and material design, but only when the adopted model reflects a correct physical picture. Paradigmatic is the case of cis-diaminodichloroplatinum(II), cis-[Pt(NH3 )2 Cl2 ], for which the correct simulation of the structural and vibrational properties measured experimentally still remains an open question. By using this molecule as ...

The production of platinated derivatives of nucleic acid bases resulting from the reaction of cis and trans DDP with DNA and chromatin was studied. Bifunctional complex of guanine appeared to be the major product of the interaction of cis isomer with both DNA and chromatin, although other bifunctional adducts of A-Pt-G and A-Pt-A were also isolated. The main product of the interaction of trans ...

The new complexes of Cr(III), Mn (II), Fe(III) and Cu(II) complexes with the chalcone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cisplatin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was teste...

A new diphosphine ligand assembled on the cyclotriphosphazene platform forms linear chelate and dimetallic bridged complexes with Au(I) and a cis-chelate complex with Pt(II).

It was serendipitously observed that cis-[PtCl2(NCEt)PPh3] reacted differently with either racemic or enantiopure 4-aza[6]helicene, giving respectively cis (racemic) and trans (enantiopure) [Pt(II)Cl2(4-aza[6]helicene)PPh3] complexes. This unexpected reactivity is explained through a dynamic process (crystallization-induced diastereoselective transformation) and enables a new aspect of reactivi...

Abstract We developed a novel method for production of no-carrier-added (n.c.a.) [ 188, 189, 191 Pt]Pt II Cl 4 2− from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[Pt 2 (NH 3 ) ] ([*Pt]cisplatin) [*Pt]Pt . was prepared as synthetic precursor *Pt complex by combination resin extraction anion-exchange chromatography after the selective reduction IV 6 with ascorbic acid. The ligand...

Twenty two new Pt(II) and Pt(V) complexes with 3.5-disubstituted hydantoins and spiro-5’hydantoins were synthesized and studied. Pt(II) complexes have been prepared as structural analogues of cisplatin with different carrier ligands. Pt(IV) complexes were with general formula cis-[PtL2Cl4]. Platinum complexes were studied in vitro for cytotoxic activity on panel of human tumor cell lines. The c...

attracted considerable attention in recent years due to their diverse structural possibilities and relevance in materials science.1–3 Mononuclear cis complexes, [M(ER)2L2], are useful precursors for the synthesis of biand poly-nuclear complexes.2,3 These complexes are usually derived from simple organochalcogenolate ions. Internally functionalized organochalcogenolates, such as 2-selenopyridina...

The color expression of anthocyanins can be affected by a variety of environmental factors and structural characteristics. Anthocyanin acylation (type and number of acids) is known to be key, but the influence of acyl isomers (with unique stereochemistries) remains to be explored. The objective of this study was to investigate the effects of cis-trans configuration of the acylating group on the...