The inducible enzyme catalysing the conversion of cis,cis-muconate to (+)-muconolactone was purified 300-fold from the yeast Trichosporon cutaneum, grown on phenol. The enzyme has a sharp pH optimum at pH 6.6. It reacts also with several monohalogen derivatives and with one monomethyl derivative of cis,cis-muconate, but not with cis,trans- or trans,trans-muconate or 3-carboxy-cis,cis-muconate. ...

The pure rotational spectrum of cis-cis peroxynitrous acid, HOONO, has been observed. Over 220 transitions, sampling states up to J'=67 and Ka'=31, have been fitted with an rms uncertainty of 48.4 kHz. The experimentally determined rotational constants agree well with ab initio values for the cis-cis conformer, a five-membered ring formed by intramolecular hydrogen bonding. The small, positive ...

Abstract Cisplatin is one of the most commonly used chemotherapy in lung cancer despite its high nephrotoxicity leading to an administration only every 3–4 weeks. This study first report a preclinical investigation therapeutic intensification combining cisplatin dry powder for inhalation (CIS-DPI) with intravenous (iv) cisplatin-based treatment. CIS-DPI 50% content (CIS-DPI-50) was developed us...

Cis-stereoregulated poly(phenylacetylene) [poly(PA)] was synthesized by polymerization of PA using Rh catalysts, and the thermal isomerization behavior analyzed DSC, 1H NMR, IR Raman spectroscopies. Cis-poly(PA) exhibited DSC exothermic peaks around 170 °C corresponding to main chain from cis trans. The content decreased 12% after heating at °C, became almost zero 180 which determined NMR spect...

cis-polybutadiene was functionalized using in–situ generated dmd as oxidant and tetra-n-butyl ammonium bromide as phase transfer catalyst (ptc). the epoxidation process was investigated by 1hnmr spectroscopy. 1hnmr spectrum analysis of products confirms the absence of ring opening side products in epoxidation reaction. various factors such as reaction temperature, reaction time and the concentr...

Reaction of thionyl chloride with 2-acetyl-1- benzenesulfonylpyrrole semicarbazone (6 c) gave 4 - (1- benzenesulfonyl-2 - pyrrolyl) - 1, 2, 3 -thiadiazole (lc). Selenium dioxide oxidation of 2-acetylpyrazine semicarbazone (10) in acetic acid afforded 4- (2-pyrazinyl) - 1, 2, 3- selenadiazole (4). Reaction of thionyl chloride with compound 10 gave 4- (2-pyrazinyl) - 1, 2, 3- thiadiazole (3)....

The intermolecular [2 + 2]-photocycloaddition of the parent flavone molecule (4) as triplet energy-accepting species and electron-rich alkene 2, 3-dihydrofuran (5) was performed by visible-light-mediated triplet-sensitization with an iridium-based organometallic sensitizer. reaction proceeds high diastereo- regioselectivity (>98:2 for regiochemical orientation 95% d.s.). In contrast to numer...

catalytic osmylation of cis and trans 2-cyclohexene-cyclohexanol (1a) and (1b) are carried out in the presence of n-methyl morpholine-n-oxide. under the same conditions, only the cis isomer reacted, leading to triol (3). the steric hindrance of the equatorial oh group probably prevents the trans isomer from entering into such reaction. triol (3) was also obtained from the reduction of the diol-...

Introduction: Cochlear implantation (CI) improves language skills among children with hearing loss. However, children with CIs still fall short of fulfilling some other needs, including musical perception. This is often attributed to the biological, technological, and acoustic limitations of CIs. Emotions play a key role in the understanding and enjoyment of music. The present study aimed to in...