Sir, Many patients come with vertigo as their presenting symptom. They have been to physicians/neurologists/ENT specialists and have been fully investigated and treated symptomatically without any positive findings or relief. On detailed probing, these patients are found to be cases of depression-mostly of retarded variety. There is no specific age, sex, domicile or socioeconomic distribution o...

The purpose of this study is to determine the prevalence and the patterns of movement disorders (MD) in outpatients submitted to the chronic use of cinnarizine (cz) or flunarizine (fz), and to establish the main risk factors for MD development. Over a period of 3 months, data were collected from outpatients who were chronic users of cz or fz in a municipal health institute. A total of 26 outpat...

The challenge in developing oral drug delivery systems of poorly soluble basic drugs is primarily due to their pH dependent solubility. Cinnarizine (CNZ), a model for a poorly soluble basic drug, has pH dependent solubility; where it dissolves readily at low pH in the stomach and exhibits a very low solubility at pH values greater than 4. It is also characterized by a short half life of 3-6h, w...

An accurate, precise and sensitive reverse-phase high-performance liquid chromatography (RP-HPLC) bioanalytical approach was developed for the simultaneous estimation of cinnarizine (CIN) domperidone (DOM) in rat plasma using irbesartan (IRB) as an internal standard (IS). The proposed RP-HPLC validated per latest ICH M10 guidelines. analytes (CIN DOM) IS were extracted from samples protein prec...

Lipid based formulations (LBFs) can enhance oral bioavailability, however, their utility may be restricted by low drug loading in the formulation. Converting drugs to drug-ionic liquids (drug-ILs) or lipophilic salts significantly increase lipid solubility but this approach is complicated some cases salt disproportionation, leading a reduction and physical instability. Here we explore stability...