Dr. Yas Kuno was a pioneer in the field of sweat gland physiology. He trained many research scientists who formed the first generation of thermal physiologists. In turn, these investigators recruited qualified investigators, forming the second and third generations of thermal physiologists. At present, the third and fourth generations of investigators are actively engaged in research, expanding...

Corresponding author: Borislav D. Dimitrov Primary Care and Population Sciences Faculty of Medicine University of Southampton Level C, Southampton General Hospital Tremona Road SO166YD Southampton, UK Phone: +442381206138 Fax: +442381206529 E-mail: [email protected] 1 Halberg Chronobiology Center, University of Minnesota Medical School, Minneapolis, USA 2 School of Medicine, Pharmacy and H...

Melatonin, following discovery in the bovine pineal gland, has been detected in several extra-pineal sources including gastrointestinal tract or gut. Arylalkylamine N-acetyltransferase (AANAT) is the key regulator of its biosynthesis. Melatonin in pineal is rhythmically produced with a nocturnal peak in synchronization with environmental light-dark cycle. A recent study on carp reported first t...

More than 270 years ago plants played the pivotal role in a remarkable discovery: Organisms possess within themselves a surprisingly accurate timing device that synchronizes physiology with the daily environmental cycle. The field of circadian biology arose from the curious observation of de Mairan in 1729 that the daily leaf movements of plants (Mimosa pudica) persisted for several days after ...

A number of recent studies have debated the existence and nature of clocks outside the suprachiasmatic nucleus that may underlie circadian rhythms in conditions of food entrainment or methamphetamine administration. These papers claim that either the canonical clock genes, or the circuitry in the dorsomedial nucleus of the hypothalamus, may not be necessary for these forms of entrainment. In th...