OBJECTIVE To demonstrate the long-term efficacy of intranasal furosemide, an inhibitor of the sodium chloride cotransporter channel at the basolateral surface of the respiratory epithelial cell, vs no therapeutic intervention vs intranasal mometasone furoate, a corticosteroid, in preventing relapses of chronic hyperplastic sinusitis with nasal polyposis. DESIGN Randomized prospective controll...

Abstract Aims Anecdotal evidence suggests an increase in the incidence of cases Chronic Fungal Sinusitis pre- and post-Covid 19 Pandemic. We aimed to audit our patient fungal sinusitis post-COVID-19 pandemic, alongside auditing management these against national guidelines. Objectives: 1. To assess pandemic at a single UK Tertiary centre 2. patients guidelines post- COVID-19 pandemic. Methods Al...

BACKGROUND Eosinophilic chronic frontal sinusitis is difficult to treat compared with non-eosinophilic sinusitis because of recurring inflammation and polyp formation in the frontal recess after the post-operative follow-up period. Studying inflammatory mediators in the frontal recess of eosinophilic chronic rhinosinusitis (ECRS) patients and non-eosinophilic chronic rhinosinusitis (non-ECRS) p...

OBJECTIVES We assessed the effects of endoscopic sinus surgery on quality of life of patients with nasal polyposis or chronic sinusitis. PATIENTS AND METHODS Thirty patients (5 females, 25 males; mean age 36 years; range 17 to 58 years) who underwent endoscopic sinus surgery were prospectively evaluated. The diagnoses were nasal polyposis in 15 patients and chronic sinusitis in 15 patients. P...

OBJECTIVE To perform a comprehensive molecular pathways analysis of genes identified through genome-wide expression profiling and the published literature for chronic sinusitis with polyps. STUDY DESIGN Molecular pathways analysis. SETTING Academic medical center. METHODS A molecular pathways analysis of gene biomarkers discovered through hypothesis-driven and high-throughput molecular st...

BACKGROUND Chronic sinusitis (CRS) is a common otorhinolaryngologic disease that is frequently encountered in everyday practice, but there is a lack of precise data regarding the prevalence of CRS in developing countries. We performed a national investigation in China to determine the prevalence and associated factors of CRS. METHODS We conducted a cross-sectional investigation in 2012. A str...

Back Ground: Sinusitis affects millions of people each year and is a major cause of concern worldwide. Chronic rhino-sinusitis is an inflammation of Nose and Paranasal sinuses and the aetiology of it is multifactorial. Anatomical variations of nose and paranasal sinuses are one of the most important aetiological factor for chronic sinusitis. The approach to patients with chronic rhinosinusitis ...

<p class="abstract">Sinonasal diseases are serious health issues found in the clinical practice. Sinonasal often associated with anatomical variants sinonasal tract. There numerous frequently computed tomography (CT) scans of paranasal sinuses. Middle turbinate concha bullosa is a common variant nasal cavity. Pneumatization middle called as bullosa. The pneumatization mostly via anterior ...

Chronic sinusitis is a disease that afflicts a significant percentage of the population and causes considerable long-term morbidity. The common use of multiple broad-spectrum oral antibiotics and endoscopic sinus surgery to treat this condition may alter the pathogenes that promote persistence of chronic sinusitis. Forty-eight culture-positive patients with chronic sinusitis who had been medica...

OBJECTIVE To investigate the effects of mucokinetic drugs on the rheological properties of human nasal mucus in patients with chronic sinusitis. DESIGN We reconstituted human nasal mucus obtained from 74 patients with chronic sinusitis and determined the effects of 4 mucokinetic drugs, including acetylcysteine, deoxynuclease I, 2% sodium bicarbonate, and a combination product containing tylox...