Background. Levels of MBCK can be increased in patients with skeletal muscle injury or renal failure in the absence of myocardial injury, causing diagnostic confusion. This study was designed to determine whether measurement of cardiac troponin I (cTnI), a myocardial regulatory protein with comparable sensitivity to MBCK, has sufficient specificity to clarify the etiology ofMBCK elevations in p...

Chronic metabolic diseases are on the rise worldwide and their etiology is multifactorial. Among them, inflammatory components like Tumor Necrosis Factor (TNF), contribute to whole-body impairment. Caloric Restriction (CR) combats diseases, but how it reduces inflammation remains understudied. We aimed evaluate impact of chronic CR muscle inflammation, in particular TNF. In our study, 4-week ol...

The effects of chronic hypoxia (CH) on respiratory muscle are poorly understood. The aim of the present study was to examine the effects of CH on respiratory muscle structure and function, and to determine whether nitric oxide is implicated in respiratory muscle adaptation to CH. Male Wistar rats were exposed to CH for 1-6 weeks. Sternohyoid and diaphragm muscle contractile properties, muscle f...

The purpose of this study was to investigate the effect of chronic moderate-intensity training in order to prevent muscle atrophy with a focus on TNF-α and atrogin-1/MAFbx as main proteolytic indicators. Hindlimb unloading model of mice received treadmill running exercise for 1 hr per day during hindlimb unloading period of 6 weeks. The gastrocnemius muscle mass, muscle fiber cross-sectional ar...

objective(s): pregabalin (pgb) is a new antiepileptic drug that has received fda approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. this study was undertaken to evaluate the possible adverse effects of pgb on the muscular system of mice. materials and methods: to evaluate the effect of pgb on skeletal...

Purpose: To investigate the effect of single session Extracorporeal Shock Wave Therapy (ESWT) over the ankle plantar flexor muscles on the spasticity, muscle architecture, and gait in chronic stroke patients. Methods: This quasi-experimental, single group study had a repeated measures design. A total of 17 post-stroke patients were selected by convenience sampling method, and received 2000 sho...

  Background: Alterations in the neuromuscular control of the spine were found in patients with chronic low back pain (CLBP). Sudden loading of the spine is assumed to be the cause of approximately 12% of lower back injuries. However, some aspects of this problem, such as alterations in the sensory–motor control of the spine, remain questionable. This study investigated postural and neuro–motor...