At initial presentation, chronic recurrent multifocal osteomyelitis may mimic acute hematogenous osteomyelitis; however, cultures of affected bone are sterile. Nuclear scintigraphy identifies additional foci of involvement that present concurrently or sequentially. Unlike acute bacterial osteomyelitis, chronic recurrent multifocal osteomyelitis seems unaffected by antibiotic therapy and typical...

Background SAPHO is a heterogeneous autoinflammatory disease, characterized by bone and joint involvement wide variety of dermatologic manifestations, including palmo-plantar pustulosis (PPP), acne, hidradenitis suppurativa (HS), pyoderma gangrenosum (PG), psoriasis, Snedd-Wilkinson disease Sweet syndrome. In children, the osteo-articular manifestations are chronic recurrent multifocal osteomye...

BACKGROUND Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory, non-infectious osteopathy that affects predominantly patients </= 18 years of age. There is no uniformly effective treatment. Our objective is to describe clinical, magnetic resonance imaging (MRI), and bone resorption response to intravenous pamidronate in pediatric CRMO. METHODS We report our prospectively docu...

CRMO is an autoinflammatory disease of children and young adults, characterized by the insidious onset of local pain and swelling in affected bone and fever. The bone lesions are radiologically characterized as multiple luciens surrounded by defined zones of patchy but dense sclerosis, cortical tickening from periosteal new bone formation, and increased bone size with different bones involved. ...

Results Six patients were assessed (34 females and 6 males) with a median age at diagnosis of 9,5 yrs (range 5-16). Median number of initial bony lesions was 2 at onset and 3.5 over disease course. Median time since diagnosis was 1.5 yrs) and median duration of active disease 0.7 yrs. Two patients had active disease at follow-up and continued to have pain. Two patients were treated with steroid...

Results The median age of symptom onset was 8,2 years, while the patients were diagnosed to have CRMO at a median of 10 years of age. Eight out of nine patients presented with extremity pain, while five of the patients had back pain on presentation. Eight out of nine patients presented with extremity pain, while five had back pain on presentation. The patients had a median of three lesions at t...

Chronic nonbacterial osteomyelitis, or its most severe form, chronic recurrent multifocal is an autoinflammatory bone disease that causes skeletal inflammation characterized by pain and swelling primarily affects children. It a diagnosis of exclusion clinical presentation may mimic underlying infectious processes malignancy. Clinical suspicion for this timely referral to pediatric rheumatology ...

Chronic recurrent multifocal osteomyelitis is an autoinflammatory disorder characterized by bone pain and fever, a course of exacerbations and remissions, and a frequent association with other inflammatory conditions. Because its etiology is largely unknown, the diagnosis is still based on clinical criteria; treatment is empiric and not always successful. The diagnosis is supported by the prese...

We describe 22 patients who presented between the ages of 4 and 14 years with gradual onset of malaise and pain at the sites of multiple bone lesions. The symptoms from the bone lesions were sometimes sequential in onset and often relapsing. The radiological findings were typical of osteomyelitis. Radioisotope bone scans identified some clinically silent lesions. Bone biopsies were performed in...