Sarcoidosis is a chronic granulomatous disease of unknown etiology occurring world wide. The problem of diagnosis of sarcoidosis in a country like Pakistan is two fold: lack of awareness of its existence and difficulty in differentiating it from the highly prevalent tuberculosis with which it shares many clinical and pathological features. It can affect almost any organ. We present a case with ...

http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary.org/site/subscriptions/index.xhtml Information abo...

Introduction: Invasive fungal sinusitis, though considered to be rare entity, is nowadays frequently encountered, not only in immunocompromised patients but also in immunocompetent patients. The changing prevalence towards immunocompetent hosts is due to the indiscriminate usage of broad spectrum antibiotics, steroids, and immunosuppressive drugs. Diagnosing invasive fungal sinusitis should not...

BACKGROUND Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue granuloma formation. CASE PRESENTATION We describe a case of X-linked Chronic granulomatous disea...

Granulomatous colitis is a chronic transmural disease of unknown etiology gastro-intestinal tract. It can affect any area the GI In recent decades, there has been an increase in number cases disease, which be explained by improvement diagnostic methods on one hand, and deterioration environmental factors other hand. The main intestinal complications granulomatous are: obstruction, perforation, ...

A common problem associated with longitudinal studies is the dropouts of subjects or censoring before the end of follow-up. In most existing methods, it is assumed that censoring is noninformative about missed responses. This assumption is crucial to the validity of many statistical procedures. We develop some nonparametric hypothesis testing procedures to test for independent censoring in the ...

The role of reduced glutathione in relation to hexose monophosphate shunt activity and peroxide detoxification has been well established in human erythrocytes. Less is known about the content of reduced glutathione in phagocytic leukocytes and the changes that occur during functional activity. We have measured the reduced sulfhydryl content of normal resting human granulocytes and of cells isol...