I N 1930, Brewster and Cannon’#{176} reported the first example of acute leukemia in a case of mongolism ( Down’s syndrome ) . Between 1947 and 1963, further reports appeared demonstrating the increased incidence of acute leukemia in Down’s syndrome.7”’#{176}”5’48’49’6#{176}’65’M7’#{176}’ In 1958, Stewart et al.TM5 reported that of 677 children dying of leukemia, 18 were associated with Down’s ...

We have studied maternal serum free beta-hCG and PAPP-A, and fetal nuchal translucency (NT) in a series of 46 cases of fetal Turner's syndrome, 13 cases of other sex chromosomal anomalies and compared these with 947 control pregnancies in the first trimester. In cases of Turner's syndrome (45,X) the median fetal NT was significantly higher than in controls (4.76 MoM), the median PAPP-A was sign...

The objective of the present study was to determine the frequency of somatic chromosomal anomalies and Y chromosomal microdeletions (azoospermia factor genes, AZF) in infertile males who seek assisted reproduction. These studies are very important because the assisted reproduction techniques (mainly intracytoplasmic sperm injection) bypass the natural selection process and some classical chromo...

PURPOSE To assess the regional patterns of infant mortality due to lethal congenital anomalies, and the potential reasons for the regional patterns. METHOD The study analyzed 2,507 infant deaths due to lethal congenital anomalies among 1,178,452 live births in 9 of the 12 Canadian provinces and territories from 1990 to 1995 recorded in Statistics Canada's live birth and death data bases. RE...