Background: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutat...

background: cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (rsas). the aim of this study was to detect chromosome abnormalities in couples with rsas and to compare our results with those reported previously. materi...

the spalacidae are southeast european and east mediterranean blind rodents, highly adapted for life underground. their taxonomy needs a modern revision including chromosomal data as well as morphology. mole rats of the family spalacidae range over turkey and approximately 30 karyotypes of nannospalax complex inhabit. the diploid number of chromosome of nannospalax ranges from 36 to 62. also, fu...

background: chromosomal disorders are the most common cause of first trimester spontaneous abortion. among the human chromosomes, chromosome no.9 was the most common structural chromosomal variant and it is not thought to be of any functional importance, which often considers as a normal variation in structural polymorphisms, nevertheless there are some studies which claim that there is an asso...

the indications and results of cytogenetic analysis of 521 amniotic cell cultures performed at 13-16 weeks of gestation were evaluated in this study. 507 fetuses (97.3%) were cytogenetically normal, 14 (2.7%) had unbalanced karyotypes, and 2 fetuses were found to have major abnormalities, one with anencephaly detected by measurement of alpha -fetoprotein levels in amniotic fluid and ultrasonogr...

background: fetal nasal bone assessment is a non-invasive procedure that helps provide even greater assurance to patients undergoing their first trimester risk assessment for aneuploidies. absence or presence of this factor is different in some races. objective: the study was aimed to evaluate nasal bone in the first trimester of pregnancy in the indigenous population of khuzestan province, and...

This article has no abstract.

background: the major aneuploidies that are diagnosed prenatally involve the autosomal chromosomes 13, 18, and 21, as well as sex chromosomes, x and y. because multiplex ligation-dependent probe amplification (mlpa) is rapid and non-invasive, it has replaced traditional culture methods for the screening and diagnosis of common aneuploidies in some countries. objective:  to evaluate the sensitiv...

The plant Ranunculus acris (L.) is widespread. It used in folk medicine. use of herbal medicines can have adverse effects on humans and requires studies raw materials for genotoxicity. goals the study were to examine toxic genotoxic aqueous solutions R. flowers at concentrations 0.625%, 1.25%, 2.5%, 5% 10% using Allium test determine numbers flavonoids polyphenols antioxidant activity extracts....

introduction: fluorscence in situ hybridization (fish) enables specific detection of unique sequences of varying length, chromosomal regions or entire chromosomes within metaphase or interphase cells. recent developments in this technology permit the rapid mapping and ordering of dna fragments on single metaphase chromosome bands. the technique of fish incorporates several stages including: pro...