Administration of large doses of thyroid hormone preparations (desiccated thyroid powder, thyroxine, triiodothyronine, diiodotyrosine) to cholesterol-fed chicks was associated with decreased rate of weight gain and partial inhibition of hypercholesterolemia. Consistent, definitive inhibition of aorta and coronary atherogenesis was not observed, despite partial suppression of hypercholesterolemi...

BACKGROUND Immunoinflammatory mechanisms are implicated in the atherogenic process. The polarization of the immune response and the nature of the immune cells involved, however, are major determinants of the net effect, which may be either proatherogenic or antiatherogenic. Dendritic cells (DCs) are central to the regulation of immunity, the polarization of the immune response, and the inductio...

The Δ32-CCR5 deletion of the CCR5 receptor is protective toward coronary artery pathology and myocardial infarction. Maraviroc (MVC), a CCR5 antagonist, was recently introduced in the therapy of HIV infection; we evaluated whether this drug could modulate the atherosclerotic burden in aviremic PI-treated HIV-positive individuals who underwent MVC intensification. Thus, the effect of MVC on inti...

OBJECTIVE To assess biochemical, anthropometric, and dietary variables considered risk factors for coronary artery disease. METHODS Using anthropometrics, dietary allowance, and blood biochemistry, we assessed 84 patients [54 males (mean age of 55+/- 8 years) and 30 females (mean age of 57+/-7 years)], who had severe (>/= 70% coronary artery obstruction) and nonsevere forms of coronary artery...

The importance of legumes in sustainable cropping systems has been studied extensively. Among legumes, common beans (Phaseolus vulgaris L.) are a rich world resource biodiversity with two centers domestication (Andes and Central America) over 10 major market classes cultivated globally. Common recognized as nutrient-dense, healthy food source due to their high protein, dietary fiber, minerals c...

Abstract High cholesterolemia is a key risk factor for the development of cardiovascular diseases, which are main cause mortality in developed countries. Most therapies focused on modulation its biosynthesis through 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR) inhibitors. In this sense, food-derived bioactive peptides might act as promising health alternatives their ability to int...

From the Cardiovascular Department, Medical Research Institute, Michael Reese Hospital, Chicago, HI. This department is supported by the Michaol Reese Research Foundation. Supported by grant no. H-2276 from too National Heart Institute and a grant from the Chicago Heart Association. Reported initially before the Midwest Section of the American Federation for Clinical Research, October 31, 1957....

background: atherosclerosis is one of the most important cardiovascular diseases that involve vessels through the development of fatty streaks and plaques. plant?based compounds can help treat or prevent atherosclerosis through affecting the involved factors. the main purpose of this review article is to investigate and introduce medicinal plants and their potential activities regarding antioxi...

Angiotensin (ANG)-(1-7) constitutes an important functional end-product of the renin-angiotensin-aldosterone system that acts to balance the physiological actions of ANG II. In the kidney, ANG-(1-7) exerts beneficial effects by inhibiting growth-promoting pathways and reducing proteinuria. We examined whether a 2-wk treatment with a daily dose of ANG-(1-7) (0.6 mg·kg(-1)·day(-1)) exerts renopro...