Diarrhea caused by Vibrio cholerae O1 (and occasionally O139) remains a notable disease burden in much of the developing world, affecting several million individuals and leaving an estimated toll of 100,000 deaths annually (52). Outbreaks with unacceptably high case fatality rates continue to occur in areas of extreme poverty, overcrowding, and poor sanitary conditions, often accompanying natur...

The Gram negative bacterium, Vibrio cholerae (Vc) causes cholera, an enteric disease that has killed untold numbers of humans. In the 19 th century, whole-cell (W-C) cholera vaccines were tested in humans. Field trials (1960s70s) of injected, killed W-C (kW-C) Vc showed cholera-specific immune responses (antibodies, Abs) could be induced with a single dose in certain cohorts, but more durable i...

background and objectives: cholera is an endemic diarrheal disease in iran, caused by vibrio cholerae . the epidemiology, transmission route, environmental determinants and antimicrobial resistant pattern of cholera have been changed during recent years. in this study the epidemiology and antimicrobial resistance of cholera in iran during 2013 outbreak was investigated. materials and methods: a...

BACKGROUND Young children are one of the most vulnerable groups who may be infected with cholera. The following literature review of the efficacy of the currently available cholera vaccines provides a clear evidence base for the clinical administration of cholera vaccine, particularly in an epidemic situation. AIM To assess the efficacy of oral cholera vaccines in preventing cases of cholera ...

background several hundred thousand people are infected with vibrio cholera every year worldwide, with a case fatality rate over 2%. periodic cholera outbreaks are of important health issues in iran, especially in sistan and baluchistan province. objectives in this study, we evaluated cholera out breaks and related factors, during 2010-2013, to improve controlling the disease in this province. ...

Cholera outbreak is more common in developing countries. The causative agent of the disease is Vibrio cholerae strains O1 and O139. Traditional diagnostic testing for Vibrio is not always reliable, because Vibrio can enter a viable but non cultivable state. Therefore, nucleic acid-based tests have emerged as a useful alternative to traditional enrichment testing.       In this investigation, a...

With limited healthcare resources, rational prioritization of healthcare interventions requires knowledge and analysis of disease burden. In the absence of actual disease-burden data from less-developed countries, various types of morbidity and mortality estimates have been made. Besides having questionable reliability, these estimates do not capture the full burden of a disease since they prov...