Two phenothiazine compounds, trifluoperazine and chlorpromazine, inhibited growth in vitro of the five most common pathogenic yeasts, with MICs ranging from 10 to 40 micrograms/ml. Daily intraperitoneal injections of trifluoperazine (4 to 7 mg/kg of body weight) increased the survival of mice experimentally infected with Candida albicans or Cryptococcus neoformans. The potential use of these dr...

A series of amino derivatives of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0(2.6)]dec-8-ene-3,5-dione, analogues of chlorpromazine and aminoperazine have been prepared. These compounds are expected to have antipsychotic and/or anti HIV activity. Molecular structure of III was confirmed by an X-ray structure analysis. The cytotoxicity and anti HIV activity of derivatives I-IV were determined.

Among a series of clinically available psychopharmacological agents chlorproma zine is known to be effective against the reactive or neurotic depressive disorders with little effect on the endogenous depression, while imipramine is described to be very effec tive against the endogenous disorders by activating the psychic processes rather than by sedating. Therefore, the comparison of the pharma...

and substrate are in direct contact, and the solubility of chlorpromazine therefore appears greater. These previous investigators have fitted data to a normaf Scatchard plot, though there are signs of the plots having been forced through the points at low concentrations. The present results, taken in conjunction with previous ones, indicate a close similarity between chlorpromazine binding to a...

For the first time electron spin resonance (ESR) spectroscopic technique has been used for a highly selective determination of chlorpromazine. The method is based on the oxidation reaction of chlorpromazine with cerium(IV) in sulfuric acid media. In this method 3.8x10(-3) mol dm(-3) cerium(IV) was used in 0.035 mol dm(-3) sulfuric acid with the ESR spectra recorded at room temperature. A calibr...

An Aotus-Plasmodium falciparum model was used to determine if chloroquine resistance could be reversed in vivo. The putative resistance modulators tested all reverse chloroquine resistance in vitro and included verapamil, chlorpromazine, prochlorperazine, cyproheptadine, ketotifen, a tiapamil analog (Ro 11-2933), and a chlorpromazine analog (SKF 2133-A). Combinations of chloroquine plus chlorpr...

To delineate further the underlying mechanism by which amphiphilic drugs can modulate vesicle release from human RBCs, we studied the effect of chlorpromazine on erythrocyte vesiculation induced by ATP depletion. This was correlated with turnover of the phosphoinositides as well as RBC deformability during the process since phosphoinositide metabolism may be involved in shape regulation of RBCs...

The effects of three premedication regimens were compared in 45 healthy patients in whom anaesthesia was induced with diprivan 2 mgkg" I.V Premedication with diazepam 10 mg orally and droperidol 2.5-5 Omg and piritramide 7.5-15.0 mg i.m. resulted in less pain on injection and a more profound sleep from dipnvan than premedicanon with diazepam 10 mg orally or no premedication. No differences in s...

Chlorpromazine was synthesized in December 1951 in the laboratories of Rhône-Poiulenc, and became available on prescription in France in November 1952. Its effectiveness was reflected in the transformation of disturbed wards; its commercial success stimulated the development of other psychotropic drugs. Recognition of chemical mediation at the site of the synapse, followed by the introduction o...

conclusions this study showed that, compared to simply increasing the dose of morphine, adding chloropromazine, promethazine, midazolam, and clinidine to morphine significantly controlled pain scores and increased treatment satisfaction in addicted patients without notable side effects. objectives the objective of this study was to evaluate the analgesic effects of adding clonidine, promethazin...